Conjugates having improved characteristics for in vivo administr

Details Conjugates having improved characteristics for in vivo administr Conjugates having improved characteristics for in vivo administr

1989-12-29

1992-05-26

Moezie, F. T.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530363, 5303919, 530402, 530403, 5303917, 5303911, 530866, 424 8591, C07K 1702

Patent

active

051169444

ABSTRACT:
Conjugates comprising a therapeutically effective proteinaceous active moiety linked to an albumin moiety which exhibit enhanced serum half-life and stability properties are disclosed. The conjugates may additionally comprise targeting moieties to facilitate selective localization of the active moiety at a target site. Conjugates of the present invention comprising an albumin moiety additionally exhibit reduced toxicity, yet maintain a high degree of selectivity and potency.

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