Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-12-15
1996-05-28
Feisee, Lila
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
4241471, 4241781, 4241591, 424 931, 5303883, 536 231, C07K 1608, A61K 3942, C12N 700, C07H 1900
Patent
active
055212913
ABSTRACT:
Conjugates in which a virus is bound via an antibody to a substance having an affinity for nucleic acid, for transporting gene constructs into higher eucaryotic cells. Complexes of the conjugates and nucleic acid are internalized in the cell, whilst the virus as part of the complex brings about the internalization and the release of the contents of the endosomes, in which the complexes are located after entering the cell. Pharmaceutical preparations in which the nucleic acid is a therapeutically active gene construct, particularly for use in gene therapy.
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Birnstiel Max L.
Cotten Matthew
Curiel David T.
Hu Ping-chuan
Wagner Ernst
Boehringer Ingelheim International GmbH
Feisee Lila
Genentech Inc.
University of North Carolina at Chapel Hill
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