Conjugates for bone imaging and bone cancer therapy

Details Conjugates for bone imaging and bone cancer therapy Conjugates for bone imaging and bone cancer therapy

1991-01-31

1993-04-13

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

252625, A61K 4902

Patent

active

052021092

ABSTRACT:
The present invention provides conjugates formed from calcified tissues targeting agents and radiolabeled compounds. One such conjugate comprises a chelate and a targeting agent that is capable of associating with calcified tissue, wherein the chelate contains at least one nitrogen atom or at least one sulfur atom or combinations thereof as the donor atoms.
Another aspect of the invention provides method for using the conjugates for diagnostic and therapeutic purposes, including those related to bone cancer.

REFERENCES:
patent: 3852414 (1974-12-01), Adler et al.
patent: 3974268 (1976-08-01), Subramanian et al.
patent: 3987157 (1976-10-01), Molinski et al.
patent: 3989730 (1976-11-01), Subramanian et al.
patent: 4016249 (1977-04-01), Adler et al.
patent: 4017595 (1977-04-01), Subramanian et al.
patent: 4032625 (1977-06-01), Subramanian et al.
patent: 4082840 (1978-04-01), Adler et al.
patent: 4115541 (1978-09-01), Subramanian et al.
patent: 4233284 (1980-11-01), Fawzi
patent: 4247534 (1981-01-01), Bevan
patent: 4337240 (1982-06-01), Saklad
patent: 4439413 (1984-03-01), Hayashi et al.
patent: 4444690 (1984-04-01), Fritzberg
patent: 4504462 (1985-03-01), Van Duzee et al.
patent: 4510125 (1985-04-01), Grogg et al.
patent: 4560548 (1985-12-01), Simon et al.
patent: 4582700 (1986-04-01), Dean et al.
patent: 4606907 (1986-08-01), Simon et al.
patent: 4617184 (1986-10-01), Tsolis et al.
patent: 4638051 (1987-01-01), Burns et al.
patent: 4642229 (1987-02-01), Cumming et al.
patent: 4666698 (1987-05-01), Schwarz
patent: 4810486 (1989-03-01), Kelly et al.
patent: 4830847 (1989-05-01), Benedict et al.
patent: 4885153 (1989-12-01), Wilbur et al.
patent: 5045303 (1991-09-01), Wilbur et al.
Bodanszky et al., "The Practice of Peptide Synthesis," Reactivity and Structure Concepts in Organic Chemistry 21:138-139 (1984).
Eisenhut et al., ".sup.131 I. Labeled Diphosphonates for the Palliative Treatment of Bone Metastases-IV. Syntheses of Benzylidenediphosphonates and Their Organ Distribution in Rats," Appl. Radiat. Isot. 38:535-540 (1987).
Ketring, ".sup.153 Sm-EDTMP and .sup.186 Re-HEDP as Bone Therapeutic Radiopharmaceuticals," Nucl. Med. Biol. 14:223-232 (1987).
Marsh et al., "Uptake of Technetium-99m Diphosphonate by Metastatic Large Cell Carcinoma of the Lung," J. Nucl. Med. 29:726-728 (1988).

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