Conjugates comprising two active agents

Details Conjugates comprising two active agents Conjugates comprising two active agents

2006-02-21

2006-02-21

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

C530S380000, C530S382000, C530S384000, C530S402000

Reexamination Certificate

active

07001989

ABSTRACT:
The present invention pertains to a pharmaceutical conjugate comprising an insoluble carrier to which first and second active agents are bound, respectively via a first linker to a first functional group on the carrier and via a second linker to a second functional group on the carrier. For example, fibrinogen and Factor VIII can be independently linked to albumin microcapsules.

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Colman, R.W. et al. “Hemostasis and Thrombosis. Basic Principles and Clinical Practice” J.B. Lippincott Company, Philadelphia, pp. 29-33 (1993).
Zara, J.J. et al. “A Carbohydrate-Directed Heterobifunctional Cross-Linking Reagent for the Synthesis of Immunoconjugates”Anal Biochem., vol. 194, pp. 156-162 (1991).

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