Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-24
2010-12-28
Cordero Garcia, Marcela M (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S04400A, C514S244000
Reexamination Certificate
active
07858625
ABSTRACT:
This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules.
REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5108921 (1992-04-01), Low et al.
patent: 5334711 (1994-08-01), Sproat
patent: 5416016 (1995-05-01), Low et al.
patent: 5580969 (1996-12-01), Hoke et al.
patent: 5589332 (1996-12-01), Shih et al.
patent: 5627053 (1997-05-01), Usman et al.
patent: 5631359 (1997-05-01), Chowrira et al.
patent: 5633133 (1997-05-01), Long et al.
patent: 5672695 (1997-09-01), Eckstein et al.
patent: 5716824 (1998-02-01), Beigelman
patent: 5741679 (1998-04-01), George et al.
patent: 5814620 (1998-09-01), Robinson et al.
patent: 5834186 (1998-11-01), George et al.
patent: 5849902 (1998-12-01), Arrow et al.
patent: 5871914 (1999-02-01), Nathan et al.
patent: 5898031 (1999-04-01), Crooke
patent: 5989912 (1999-11-01), Arrow et al.
patent: 5998148 (1999-12-01), Bennett et al.
patent: 5998203 (1999-12-01), Matulic-Adamic et al.
patent: 5998206 (1999-12-01), Cowsert
patent: 6001311 (1999-12-01), Brennan
patent: 6060456 (2000-05-01), Arnold et al.
patent: 6107094 (2000-08-01), Crooke
patent: 6172208 (2001-01-01), Cook
patent: 6214805 (2001-04-01), Torrence et al.
patent: 6335434 (2002-01-01), Guzaev et al.
patent: 6346398 (2002-02-01), Pavco et al.
patent: 6362171 (2002-03-01), Suhadolnik et al.
patent: 6506559 (2003-01-01), Fire et al.
patent: 6528631 (2003-03-01), Cook et al.
patent: 6573099 (2003-06-01), Graham
patent: 6749863 (2004-06-01), Chang et al.
patent: 6824972 (2004-11-01), Kenwrick et al.
patent: 7022828 (2006-04-01), McSwiggen
patent: 7078196 (2006-07-01), Tuschl et al.
patent: 2002/0086356 (2002-07-01), Tuschl et al.
patent: 2002/0151693 (2002-10-01), Breaker et al.
patent: 2003/0059944 (2003-03-01), Lois-Caballe et al.
patent: 2003/0064945 (2003-04-01), Akhtar et al.
patent: 2003/0143732 (2003-07-01), Fosnaugh et al.
patent: 2003/0190635 (2003-10-01), McSwiggen et al.
patent: 2003/0206887 (2003-11-01), Morrissey et al.
patent: 2004/0019001 (2004-01-01), McSwiggen et al.
patent: 2004/0161844 (2004-08-01), Baker et al.
patent: 2005/0020521 (2005-01-01), Rana
patent: 2005/0182005 (2005-08-01), Tuschl et al.
patent: 2005/0227256 (2005-10-01), Hutvagner et al.
patent: 2001240375 (2001-03-01), None
patent: 2359180 (2000-08-01), None
patent: 0 360 257 (1990-03-01), None
patent: 1144623 (2002-01-01), None
patent: 1325955 (2002-01-01), None
patent: 1389637 (2002-08-01), None
patent: 08208687 (1996-08-01), None
patent: WO 89/02439 (1989-03-01), None
patent: WO 90/12096 (1990-10-01), None
patent: 90/14090 (1990-11-01), None
patent: WO 91/03162 (1991-03-01), None
patent: WO 92/07065 (1992-04-01), None
patent: WO 93/15187 (1993-08-01), None
patent: WO 93/23569 (1993-11-01), None
patent: 94/01550 (1994-01-01), None
patent: WO 95/11304 (1994-10-01), None
patent: 95/04142 (1995-02-01), None
patent: WO 95/06731 (1995-03-01), None
patent: WO 95/11910 (1995-05-01), None
patent: WO 96/10390 (1996-04-01), None
patent: WO 96/10391 (1996-04-01), None
patent: WO 96/10392 (1996-04-01), None
patent: WO 96/22689 (1996-08-01), None
patent: WO 97/26270 (1997-07-01), None
patent: WO 98/13526 (1998-04-01), None
patent: WO 98/27104 (1998-06-01), None
patent: WO 98/28317 (1998-07-01), None
patent: WO 98/43993 (1998-10-01), None
patent: WO 98/56384 (1998-12-01), None
patent: WO 98/58058 (1998-12-01), None
patent: 99/04819 (1999-02-01), None
patent: 99/07409 (1999-02-01), None
patent: 99/14226 (1999-03-01), None
patent: WO 99/16871 (1999-04-01), None
patent: WO9902530 (1999-05-01), None
patent: WO 99/29842 (1999-06-01), None
patent: 99/32619 (1999-07-01), None
patent: 99/49029 (1999-09-01), None
patent: 99/53050 (1999-10-01), None
patent: WO 99/54459 (1999-10-01), None
patent: WO 99/55857 (1999-11-01), None
patent: 99/61631 (1999-12-01), None
patent: WO 99/66063 (1999-12-01), None
patent: 00/01846 (2000-01-01), None
patent: 00/21560 (2000-04-01), None
patent: WO 00/24931 (2000-05-01), None
patent: WO 00/26226 (2000-05-01), None
patent: 00/44895 (2000-08-01), None
patent: 00/44914 (2000-08-01), None
patent: 00/49035 (2000-08-01), None
patent: 00/63364 (2000-10-01), None
patent: 01/04313 (2001-01-01), None
patent: 01/29058 (2001-04-01), None
patent: 01/36646 (2001-05-01), None
patent: 01/38551 (2001-05-01), None
patent: 01/42443 (2001-06-01), None
patent: 01/49844 (2001-07-01), None
patent: 01/53475 (2001-07-01), None
patent: 01/68836 (2001-09-01), None
patent: 01/70944 (2001-09-01), None
patent: 01/70949 (2001-09-01), None
patent: 01/72774 (2001-10-01), None
patent: 01/75164 (2001-10-01), None
patent: 01/92513 (2001-12-01), None
patent: 01/96584 (2001-12-01), None
patent: 01/97850 (2001-12-01), None
patent: 02/07747 (2002-01-01), None
patent: 02/55692 (2002-01-01), None
patent: 02/55693 (2002-01-01), None
patent: 02/10378 (2002-02-01), None
patent: 02/22636 (2002-03-01), None
patent: 02/38805 (2002-05-01), None
patent: 02/44321 (2002-06-01), None
patent: 02/096927 (2002-12-01), None
patent: 03/044188 (2003-05-01), None
patent: 03/064625 (2003-08-01), None
patent: 03/064626 (2003-08-01), None
patent: 03/068797 (2003-08-01), None
patent: 03/070887 (2003-08-01), None
patent: 03/070896 (2003-08-01), None
patent: 03/070910 (2003-08-01), None
patent: 03/074654 (2003-09-01), None
patent: 03/080638 (2003-10-01), None
patent: 2004/029212 (2004-04-01), None
patent: 2004/043977 (2004-05-01), None
patent: 2004/048566 (2004-06-01), None
patent: 2004/072261 (2004-08-01), None
patent: 2004/090105 (2004-10-01), None
patent: 2005/049821 (2005-06-01), None
Taylor et al. Pteridines. 48. Utilization of 3,3-Dimethoxy-2-pyrrolidinopropene for the Synthesis of Folic Acid, N2′-Acetyl-7-folic Acid, and 5-Deaza-7-folic Acid. J Org. Chem 1981, vol. 46, pp. 1394-1402.
Jones et al. Conjugates of Double-Stranded Oligonucleotides with Poly(ethylene glycol) and Keyhole Limpet Hemocyanin: A Model for Treating Systemic Lupus Erythematosus. Bioconjugate Chemistry. 1994, 5, pp. 390-399.
Leamon et al. Folate-targeted chemotherapy. Adv Drug Del Rev 2004. 56, pp. 1127-1141.
Leamon et al. Delivery of marcormolecules into living cells: A method that exploits folate receptor endocytosis. PNAS 1991. vol. 88, pp. 5572-5576.
Abramovitz et al., “Catalytic Role of 2′-Hydroxyl Groups Within a Group II Intron Active Site,”Science271:1410-1413 (1996).
Banerjee and Turner, “The Time Dependence of Chemical Modification Reveals Slow Steps in the Folding of a Group I Ribozyme,”Biochemistry34:6504-6512 (1995).
Bartel and Szostak, “Isolation of New Ribozymes from a Large Pool of Random Sequences,”Science261:1411-1418 (1993).
Beaucage and Iyer, “The Functionalization of Oligonucleotides Via Phosphoramidite Derivatives,”Tetrahedron49:1925-1963 (1993).
Beaudry and Joyce, “Directed Evolution of an RNA Enzyme,” Science 257:635-641 (1992).
Beigelman et al., U.S. Appl. No. 09/301,511, filed Apr. 28, 1999.
Beigelman et al., “Chemical Modification of Hammerhead Ribozymes,” J. Biol. Chem. 270:25702-25708 (1995).
Bellon et al., “Amino-Linked Ribozymes: Post-Synthetic Conjugation of Half-Ribozymes,”Nucleosides&Nucleotides16:951-954 (1997).
Bellon et al., “Post-synthetically Ligated Ribozymes: An Alternative Approach to Iterative Solid Phase Synthesis,”Bioconjugate Chem.8:204-212 (1997).
Berzal-Herranz et al., “Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme,” EBMO J. 12:2567-2574 (1993).
Berzal-Herranz et al., “In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions,” Genes & Development 6:129-134 (1992).
Bevilacqua et al., “A Mechanistic Framework for the Second Step of Splicing Catalyzed by the Tetrahymena Ribozyme,” Biochemistry 35:648-658 (1996).
Breaker, “Catalytic DNA: in training and seekin
Beigelman Leonid
Matulic-Adamic Jasenka
Cordero Garcia Marcela M
Sirna Therapeutics, Inc.
Stracker Elaine C.
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