Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2011-03-01
2011-03-01
Truong, Duc (Department: 1765)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C525S054200, C525S535000, C524S800000, C435S006120, C428S690000
Reexamination Certificate
active
07897684
ABSTRACT:
The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.
REFERENCES:
patent: 4948843 (1990-08-01), Roberts et al.
patent: 4950587 (1990-08-01), Roberts et al.
patent: 5408109 (1995-04-01), Heeger et al.
patent: 5612221 (1997-03-01), Simons et al.
patent: 5869350 (1999-02-01), Heeger et al.
patent: 5881083 (1999-03-01), Diaz-Garcia et al.
patent: 5968762 (1999-10-01), Jadamec et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6280933 (2001-08-01), Glazer et al.
patent: 6534329 (2003-03-01), Heeger et al.
patent: 6743640 (2004-06-01), Whitten
patent: 2002/0009728 (2002-01-01), Bittner
patent: 2002/0034747 (2002-03-01), Bruchez
patent: 2002/0150759 (2002-10-01), Jones
patent: 2002/0177136 (2002-11-01), McBranch
patent: 2003/0054413 (2003-03-01), Kumaraswamy
patent: 2004/0241768 (2004-12-01), Whitten et al.
patent: WO 99/35288 (1999-07-01), None
patent: WO 00/14278 (2000-03-01), None
patent: WO 00/66790 (2000-11-01), None
patent: WO 02/081735 (2002-10-01), None
patent: WO 2004/001379 (2003-12-01), None
Balakin, K.V. et al. Conjugates of oligonucleotides with polyaromatic fluorophores as promising DNA probes1:Biosensors and Bioelectronics(1998) 13:771-778.
Bardea, A. et al. Sensing and amplification of oligonucleotide-DNA interactions by means of Impedance spectroscopy: a route to a Tay-Sachs sensor;Chem. Commun. (1999) 21-22.
Baur, J.W., et al. Thin-Film Light-Emitting Devices Based on Sequentially Adsorbed Multilayers of Water-Soluble Poly (p-phenylene)s;Advanced Materials(1998) 10:17:1452-1455.
Behr, J.P. Synthetic Gene-Transfer Vectors;Acc. Chem. Res. (1993) 26: 274-278.
Behr, J.P. DNA Strongly Binds to Micelles and Vesicles Containing Lipopolyamines or Lipointercalants;Tetrahedron Lett. (1986) 27:48:5861-5864.
Benson, S.C. et al. Heterodimeric DNA-binding dyes designed for energy transfer: synthesis and spectroscopic properties;Nucleic Acids Res. (1993) 21:24:5727-5735.
Betts, L., et al, A Nucleic Acid Triple Helix Formed by a Peptide Nucleic Acid-DNA Complex;Science(1995) 270: 1838-1841.
Bhattacharya, S. and Mandal, S.S. Interaction of surfactants with DNA. Role of hydrophobicity and surface charge on intercalation and DNA melting;Biochim.et Biophys. Acta. (1997) 1323:29-44.
Bhattacharya, S. and Mandal, S.S. Role of hydrophobic effect and surface charge in surfactant-DNA association;Indian J. Biochem. &Biophys. (1997) 34:11-17.
Bier, F.F. and Kleinjung, F. Feature-size limitations of microarray technology—a critical review;Fresenius J. Anal. Chem. (2001) 371:151-156.
Birnboim, H.C. and Jevcak, J.J. Fluorometric Method for Rapid Detection of DNA Strand Breaks in Human White Blood Cells Produced by Low Doses of Radiation;Cancer Res. (1981) 41:1889-1892.
Blessing, T. et al. Monomolecular collapse of plasmic DNA into stable virus-like particles;Proc. Natl. Acad. Sci. USA(1998) 95:1427-1431.
Bronich, T.K. et al. Recognition of DNA Topology in Reactions between Plasmid DNA and Cationic Copolymers;J. Am. Chem. Soc. (2000) 122:35:8339-8343.
Cardullo, R. A. et al. Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer;Proc. Natl. Acad. Sci. USA(1988) 85:8790-9794.
Castro, A. and Williams, J.G.K. Single-molecule detection of specific nucleic acid sequences in unamplified genomic DNA;Anal. Chem. (1997) 69:19:3915-3920.
Chandar, P. et al. Fluorescence probe investigation of anionic polymer-cationic surfactant Interactions;Macromolecules(1988) 21:950-953.
Chehab, F.F. and Kan, Y.W. Detection of specific DNA sequences by fluorescence amplification: A color complementation assay;Proc. Natl. Acad. Sci. USA(1989) 86:9178.9182.
Chen, L. and Frankel, A.D. A peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA;Proc. Natl. Acad. Sci. USA. (1995) 92:5077-5081.
Chen, L. et al. Highly sensitive biological and chemical sensors based on reversible fluorescence quenching in a conjugated polymer;Proc. Natl. Acad. Sci. USA. (1999) 96:22:12287-12292.
Chen, W. et al. Using Ethidium Bromide to Probe the Interactions between DNA and Dendrimers;Langmuir(2000) 16:15-19.
Delling, U. et al. The number of positively charged amino acids in the basic domain of Tat Is critical for trans-activation and complex formation with TAR RNA;Proc. Natl. Acad Sci. USA(1991) 88:6234-6238.
Demidov, V.V. PNA and LNA throw light on DNA;Trends in Biotechnology(2003) 21:1:4-7.
Demidov, V.V. et al. Stability of peptide nucleic acids in human serum and cellular extracts;Biochem. Pharmacol. (1994) 48:6:1310-1313.
Didenko, V.V. DNA Probes Using Fluorescence Resonance Energy Transfer (FRET): Designs and Applications;BioTechniques(2001) 31:5:1106-1121.
Dogariu, A. et al. Time-resolved Förster energy transfer in polymer blends;Synthetic Metals(1999) 100:95-100.
Dufourco, J. et al, Molecular assembling of DNA with amphipathic peptides;FEBS Lett. (1998) 421:7.-11.
Eastman, S.J. et al. Biophysical characterization of cationic lipid: DNA complexes;Biochim. et Biophys. Acta(1997) 1325:41-62.
Egholm, M. et al. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogenbonding rules;Nature(1993) 365:566-568.
Egholm, M. et al. Recognition of Guanine and Adenine in DNA by Cytosine and Thymine Containing Peptide Nucleic Acids (PNA);J. Am. Chem. Soc. (1992) 114:9677-9678.
Englebienne, P. Synthetic materials capable of reporting biomolecular recognition events by chromic transition;J. Mater Chem. (1999) 9:1043-1054.
Eskilsson, K. et al. DNA-Surfactant Complexes at Solid Surfaces;Langmuir(2001) 17:1668-1669.
Felgner, P.L. et al. Nomenclature for Synthetic Gene Delivery Systems;Hum. Gene Ther. (1997) 8:511-512.
Ferguson, B.Q. and Yang, D.C.H. Localization of Noncovalently Bound Ethidium in Free and Methionyl-tRNA Synthetase Bound tRNAfMetby Singlet-Singlet Energy Transfer;Biochemistry(1986) 25:5298-5304.
Fernandez-Saiz, M. et al. A Cationic Cyclophane That Forms a Base-Pair Open Complex with RNA Duplexes;J. Am. Chem. Soc. (1996) 118:4739-4745.
Frankel, A.D. Peptide models of the Tat-TAR protein-RNA interaction;Prot. Sci. (1992) 1:1539-1542.
Futami, J. et al. Optimum Modification for the Highest Cytotoxicity of Catonized Ribonuclease;J. Biochem. (2002) 132:223-228.
Gallego, J. and Varani, G. Targeting RNA with Small-Molecule Drugs: Therapeutic Promise and Chemical Challenges;Acc. Chem Res. (2001) 34:10:836-843.
Gallo, R and Montagnier, L. AIDS in 1988;Sci. Am. (1988) 259:4: 41-48.
Ganachaud, F. et al. Adsorption of Single-Stranded DNA Fragments onto Cationic Aminated Latex Particles;Langmuir(1997) 13:701-707.
Gaylord, B. S. et al. DNA detection using water-soluble conjugated polymers and peptide nucleic acid probes;Proc. Natl. Acad. Sci. USA(2002) 99:17:10954-10957.
Gaylord, B.S. et al. Water-Soluble Conjugated Oligomers: Effect of Chain Length and Aggregation on
Bazan Guillermo C.
Liu Bin
Maher David W.
TechLaw LLP
The Regents of the University of California
Truong Duc
LandOfFree
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