Conjugated polyene sterol derivatives as membrane probes

Details Conjugated polyene sterol derivatives as membrane probes Conjugated polyene sterol derivatives as membrane probes

1989-05-31

1990-12-25

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving cholesterol

435 19, 435810, C12Q 160, C12Q 144

Patent

active

049802801

ABSTRACT:
The present invention relates to the synthesis of conjugated polyene sterol derivatives, the compounds obtained and to their use as fluorescent probes for cellular membranes. The fluorescent probes of the present invention resemble cholesterol both structurally and in amphipathic nature. The probes of the present invention have potential for use in determining cholesterol levels and cholesterol properties and cell membrane properties and can be applied to clinical assays and diagnoses involving cholesterol.

REFERENCES:
patent: 4464298 (1984-03-01), Rappoldt et al.
patent: 4477445 (1984-11-01), Philibert et al.
patent: 4680290 (1987-04-01), Cassal et al.
Alford et al., Chem. Physics Ltrs., vol. 6, No. 3 (1982) "Fluorescence of DPH . . . " Chen et al., Bio. Chem. 1977, 252-2163.
Rando et al., Biochim. Biophys. Acta, 1981, 684.
Bergeron et al., Anal. Biochem, 1982, 119, 12H.
Schroeder, FEBS Lett. 1981, 135 127.
Kao et al., Biochemistry, 1978, 17 2689.
Letourneaux et al., Chem. 1975, 40 516.
Colonna et al., J. Steroid Biochem. 1973 4 171.
Cranney et al., Biochimica et Biophysica Acta, 735 (1983) 418-425.
Schroeder, Prog. Lipid Res. 1984 23, 97.
Narwid et al., Helv. Chim. Acta, 1974 57 771.
Dusza et al. (To American Cynamid Co) U.S. 3,351,638 Nov. 7/67.
Appl Jul. 29, 1966 Pettit et al., J. Org. Chem. 1970, 35 1393.
Drew et al., J. Chem. Soc., 1985.

Affiliated with

Also associated with

Rating

Conjugated polyene sterol derivatives as membrane probes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conjugated polyene sterol derivatives as membrane probes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugated polyene sterol derivatives as membrane probes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1162288