Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1981-12-29
1983-11-29
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
4242484, 424263, 424267, 424274, 424275, 424282, 424285, A61K 2700, A61K 3134, A61K 3136, A61K 3138, A61K 3140, A61K 3144, A61K 31135, A61K 31445
Patent
active
044180799
ABSTRACT:
Conjugated ketone compounds of the formula: ##STR1## wherein Ar is naphthyl, furyl, thienyl, or phenyl optionally bearing one or more substituents selected from the group consisting of chlorine, bromine, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, trifluoromethyl and methylenedioxy, R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.7 -C.sub.8 aralkyl or adamantyl, R.sub.2 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl or C.sub.3 -C.sub.6 cycloalkyl, or when R.sub.1 and R.sub.2 are taken together with the nitrogen atom to which they are attached, they form a heterocyclic amino group containing up to 8 carbon atoms, A is straight or branched C.sub.1 -C.sub.3 alkylene, N-[4-(p-chlorophenyl)-4-oxo-2-trans-butenyl]morpholine and N-[4-(p-methoxyphenyl)-4-oxo-2-trans-butenyl]piperidine being excluded, and their non-toxic salts, which are useful as blood platelet anti-aggregative agents.
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patent: 2539801 (1951-01-01), Van Hook
patent: 3922266 (1975-11-01), Katsube et al.
patent: 3936450 (1976-02-01), Mauvernay et al.
patent: 4012515 (1977-03-01), Katsube et al.
patent: 4110447 (1978-08-01), Gante et al.
Harada Shuichi
Irie Tsunemasa
Kameno Yoshito
Katsube Junki
Kojima Atsuyuki
Friedman Stanley J.
Sumitomo Chemical Company Limited
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