Conjugated dienamides, methods of production thereof,...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from piper

Reexamination Certificate

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C426S534000

Reexamination Certificate

active

08007840

ABSTRACT:
Described are mixtures of at least four of the alkadienamides defined according to the structure:wherein R represents C1-C2n-alkyl; R1is 2-methyl-1-propyl and R2is hydrogen, or R1and R2taken together is a moiety having the formula —(CH2)n—, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of thePiperspecies,Piper longumLinn orPiper peepuloides; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

REFERENCES:
patent: 3602129 (1971-08-01), Cherre
patent: 6054585 (2000-04-01), Majeed et al.
patent: 6365601 (2002-04-01), Gaikar et al.
Yang et al., A Piperine Amide Extracted from Piper longum L. Fruit Shows Activity against Aedes aegypti Mosquito Larvae, 2002, J Agric Food Chem, 50: 3765-3767.
Gokhale et al., Chemical investigation of the fruits of Piper longum, 1948, J University of Bombaby, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 16 A: 47-52.
Nigam et al., Ethereal oil from Piper longum berries, 1965, Riechstoffe, Aromen, Koerperflegemittel, 15: 451-2, 454, 456.

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