Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Reexamination Certificate
2011-05-10
2011-05-10
Bradley, Christina (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
Reexamination Certificate
active
07939630
ABSTRACT:
Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z1and Z2independently represents a group derived from a biological molecule, each of which is linked to A and B via a nucleophilic moiety; or Z1and Z2together represent a single group derived from a biological molecule which is linked to A and B via two nucleophilic moieties; A is a C1-5alkylene or alkenylene chain; and B is a bond or a C1-4alkylene or alkenylene chain; are formed by conjugating a suitable polymer to a suitable biologically active molecule via nucleophilic groups in said molecule, preferably via a disulphide bridge.
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Brocchini Stephen James
Choi Ji-Won
Godwin Antony Robert
Pedone Elisa
Shaunak Sunil
Bradley Christina
Nixon & Vanderhye P.C.
Polytherics Limited
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