Conjugate vaccines for the prevention of dental caries

Details Conjugate vaccines for the prevention of dental caries Conjugate vaccines for the prevention of dental caries

2006-09-05

2006-09-05

Devi, S. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S197110, C424S194100, C424S234100, C424S203100, C424S184100, C424S831000, C514S023000, C514S054000, C514S835000, C530S806000, C536S123120

Reexamination Certificate

active

07101562

ABSTRACT:
The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutans streptococcus.

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