Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-12-22
1997-07-15
Ketter, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
43525233, 4352534, 4353201, 536 237, C12P 2102, C12N 120, C12N 1500, C07H 2104
Patent
active
056482418
ABSTRACT:
A purified DNA molecule is disclosed that comprises a DNA sequence encoding a Group B Streptococcus alpha antigen or antibody eliciting fragment. The alpha antigen sequence encodes several distinct domains including an N-terminal sequence that precedes the start of the alpha antigen repeating sequence, a C-terminal anchor sequence and a repeating unit motif. The ability to protect mice against a Streptococcus infection with antisera against cellular extracts containing the alpha antigen encoded by the DNA molecule was determined.
REFERENCES:
patent: 4284537 (1981-08-01), Beachey
patent: 4356170 (1982-10-01), Jennings et al.
patent: 4356263 (1982-10-01), Kasper
patent: 4367221 (1983-01-01), Kasper
patent: 4367222 (1983-01-01), Kasper
patent: 4367223 (1983-01-01), Kasper
patent: 4673574 (1987-06-01), Anderson
patent: 4757134 (1988-07-01), Blake et al.
patent: 4761283 (1988-08-01), Anderson
patent: 4789735 (1988-12-01), Frank et al.
patent: 4830852 (1989-05-01), Marburg et al.
patent: 5302386 (1994-04-01), Kasper et al.
Lerner et al. 1983, The Development of Synthetic Vaccines, in Dixon et. al. ed., Tire Biology of Immunologi Disease, pp. 331-338, Sinauer Associates, Massachusetts.
Young et al. Science, vol. 228, pp. 958-962, (1985).
Bevanger, L. et al., "The Ibc Protein Fraction of Group B Streptococci: Characterization of Protein Antigens Extracted by HCl," Acta path. microbiol. scand. Sect. B 89:205-209 (1981).
Bevanger, L., "Ibc Proteins as Serotype Markers of Group B. Streptococci," Acta path. microbiol. immunol. scand. Sect. B 91:231-234 (1983).
Brady, L. J. et al., "Identification of Non-Immunoglobulin A-Fc-Binding Forms and Low-Molecular-Weight Secreted Forms of the Group B Streptococcal .beta. Antigen," Infect. Immun. 57(5):1573-1581 (May 1989).
Coleman, R. T. et al., "Prevention of Neonatal Group B Streptococcal Infections: Advances in Maternal Vaccine Development," Obst. Gynec. 80(2):301-309 (Aug. 1992).
Feldman, R. G. et al., "The immune response to the group B streptococcus," Rev. Med. Microbiol. 3:52-58 (Jan. 1992).
Horensky, D. S. et al., "Generation and Analysis of Group B Streptococcal Alpha C Protein Gene Contructs Containing Variable Numbers of Tandem Repeats," Abstracts of the 93rd General Meeting of the Am. Soc. Microbiol., Session 107, p. 1071, Abstract D-68 (May 1993).
Kling, D. E. et al., "Group B Streptococcus C Protein Alpha Antigen Peptide Heterogeneity," Abstracts of the 93rd General Meeting of the Am. Soc. Microbiol., Session 166, p. 59, Abstract No. B-189, (May 1993).
Michel, J. L., "Group B Streptococcal Infections: An Update," Infect. Dis. Pract. 13(6):1-12 (Mar. 1990).
Michel, J. L. et al., "Genotype Diversity and Evidence for Two Distinct Classes of the C Protein Alpha Antigen of Group B Streptococcus," Twelfth Lancefield International Symposium on Streptococci and Streptococcal Diseases, St. Petersburg, Russia, Sep. 8, 1993.
Michel, J. L. et al., "Two Distinct Classes of the C Protein Alpha Antigen of Group B Streptococcus Display Phenotypic and Genotypic Diversity," Abstracts of the 1993 IDSA Annual Meeting, Clin. Infect. Dis. 17(3): Abstract No. 1 (Sep. 1993).
Ross, P. W. et al., "Group-B Streptococcus: Profile of an Organism," J. Med. Microbiol. 18:139-166 (1984).
English Abstract of European Patent Document EP 0 206 852, from Derwent World Patents Index, Dialog File 351.
Bevanger, L. et al., "Characterization of the .alpha. Antigen of the C Proteins of Group B Strepococcus (GBS) Using a Murine Monoclonal Antibody," APMIS 100: 57-62 (1992).
Madoff, L.C. et al., "Protection of Neonatal Mice from Group B Streptococcal Infection by Maternal Immunization with Beta C Protein," J. Clin. Res. 40(2): 213A (1992).
Madoff, L.C. et al., "The Cloned and Native Beta Antigens of the Group B. Streptococcal C Protein: Role in Protective Immunity," Zbl. Bakt. Suppl. 22: 363-365 (1992).
Madoff, L.C. et al., "Partial Characterization of C Protein Antigens of Group B Streptococcus," presented at the 1989 Lancefield Society Meeting, Sep. 17-20, 1989, Houston, Texas.
Michel, J.L. et al., "Characterization of the Native and Cloned C Protein Alpha Antigens of Group B Streptococcus," Zbl. Bakt. Suppl. 22: 366-367 (1992).
Madoff, L.C. et al., "Phenotypic Diversity in the Alpha C Protein of Group B Streptococci," Infect. & Immun. 59(8):2638-2644 (1991).
Heden, L-O. et al., "Molecular characterization of an IgA receptor from Group B streptococci: sequence of the gene, identification of a proline-rich region with unique structure and isolation of N-terminal fragments with IgA-binding capacity," Eur. J. Immunol. 21:1481-1490 (1991).
Jerlstrom, P.G. et al., "The IgA-binding .beta. antigen of the c protein complex of Group B streptococci: sequence determination of its gene and detection of two binding regions," Mol. Microbiol. 5(4): 843-849 (1991).
Enea, V. et al., "DNA Cloning of Plasmodium falciparum Circumsporozoite Gene: Amino Acid Sequence of Repetitive Epitope," Science 225:628-630 (1984).
Fischetti, V.A. et al., "Structure, Function, and Genetics of Streptococcal M Protein," Revs. Infect. Dis. 10(2):S356-S359 (1988).
Fischetti, V.A. et al., "Common Characteristics of the Surface Proteins from Gram-Positive Cocci," Genet. and Mol. Biol. of Streptococci, Lactococci, and Enterococci, Dunny et al., eds., Am. Soc. Microbiol. Washington, D.C. pp. 290-294 (1991).
Dailey, D.C. et al., "The Phenotypically Variable Surface Protein of Trichomonas vaginalis Has a Single, Tandemly Repeated Immunodominant Epitope," Infec. & Immun. 59(6):2083-2088 (1991).
von Eichel-Striber, C. et al., "Clostridium difficile toxin A carried C-terminal repetitive structure homologous to the carbohydrate binding region of streptococcal glycosyltransferases," Gene 96:107-113 (1990).
Anderson, B.E. et al., "A Protective protein Antigen of Rickettsia rickettsii Has Tandemly Repeated, Near-Identical Sequences," Infec. & Immun. 58(9):2760-2769 (1990).
Michel, J.L. et al., "Nucleotide Sequence Analysis of the C Protein Alpha Antigen of Group B Streptococcus," American Soc. Microbiol. 1992 Meeting Abstracts (held May 26-31, 1992), p. 69, Abstract No. B-261, mailed Mar., 1992.
Michel, J.L. et al., "Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci," Proc. Natl. Acad. Sci. USA 89:10060-10064 (1992).
Valtonen, M.V. et al., "Isolation of a C (lbc) protein from group B Streptococcus which elicits mouse protective antibody," Microbial Pathogenesis 1:191-204 (1986).
Baker, C.J. et al., "Immunization of Pregnant Women With A Polysaccharide Vaccine of Group B Streptococcus," New Eng. J. of Med. 319:1180-1185 (1988).
Kuypers, J.M. et al., "Molecular Analysis of a Region of the Group B Streptococcus Chromosome Involved in Type III Capsule Expression," Infection and Immunity 57:3058-3065 (1989).
Insel, R.A., "Maternal immunization to prevent neonatal infections," New Eng. J. of Med. 319:1219-1220 (1988).
Bevanger, L., "The Ibc proteins of group B Streptococci: isolation of the .alpha. and .beta. antigens by immunosorbent chromatography and test for human serum antibodies against the two antigens," Acta Path. Microbiol. Immunol. Scand. Sect. B 93:113-119 (1985).
Bevanger, L. et al., "Mouse-protective antibodies against the Ibc proteins of group B Streptococc," Acta Path. Microbiol. Immunol. Scand. Sect. B 93:121-114 (1985).
Russell-Jones, G.J. et al., "Identification of Protein Antigens of Group B Streptococci With Special Reference To the Ibc Antigens," J. Exp. Med. 160:1465-1474 (1984).
Ward, J. et al., "Haemophilus influenzae Vaccines," in Vaccines, pp. 300-332, S.A. Plotkin et al., eds., Saunders, Philadelphia (1988).
Ferrieri, P., "Surface-Localized Protein Antigens of Group B Streptococci," Rev. of Infect. Dis. 10(2):S363-S366 (1988).
Cleat, P.H. et al., "Cloning And Expression in Escherichia coli Of The Protein Genes of Group B Streptococci:Binding Of Human Immunoglobulin A To The Beta Antigen," Infect. And Immunity 55:1151-1155 (1987).
Avery, O.T. et al., "Chemo-Immunological Studies On Conjugated Carbohydrate-Proteins," J. Exp. Med. 54:437-447 (1931).
Bi
Ausubel Frederick M.
Kasper Dennis L.
Madoff Lawrence C.
Michel James L.
Brigham and Women's Hospital
Brusca John S.
Ketter James
The General Hospital Corporation
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