Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2005-03-29
2005-03-29
Smith, Lynette R. F. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S200100, C424S190100, C424S256100, C424S260100, C530S350000, C435S069300, C435S071200, C435S091500, C435S170000, C435S252300, C435S244000, C435S256100
Reexamination Certificate
active
06872398
ABSTRACT:
The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to which is attached the glycan of choice in vivo. Pooling of these bioconjugates produces a multivalent vaccine. These pili give high bronchial titers when delivered by the intranasal route. Mice vaccinated with pure glycosylatedP. aeruginosastrain 1244 pili in this manner are protected against respiratory challenge withP. aeruginosastrain 1244. The present invention further relates to a DNA and amino acid sequence of a new gene, pilO, which is capable of glycosylating pilin of Gram-negative bacteria and uses thereof.
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Castric Peter
Cross Alan S.
Sadoff Jerald C.
Arwine Elizabeth
Harris Charles H.
Portner Ginny Allen
Smith Lynette R. F.
The United States of America as represented by the Secretary of
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