Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-04-14
2000-05-16
Naff, David M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424450, 435176, 435178, 435179, 435180, 435325, 435366, 530300, 530329, 530331, 530811, 530813, 530814, 530815, A01N 3718, A61K 9127, A61K 4700, C12N 508, C07K 1700
Patent
active
060637595
ABSTRACT:
Methods and reagents are provided for specifically targeting biologically active compounds such as antiviral and antimicrobial drugs, or prodrugs containing the biologically active compound to specific sites such as specific organelles in phagocytic mammalian cells. The biologically active compound or prodrug is linked to a microparticle with a linker that is non-specifically or specifically cleaved inside a phagocytic mammalian cell. Alternatively, the biologically active compound or prodrug is impregnated into a porous microparticle or coated on a nonporous microparticle, and then coated with a coating material that is non-specifically or specifically degraded inside a phagocytic mammalian cell. The prodrug contains the biologically active compound linked to a polar lipid such as ceramide with a specific linker such as a peptide that is specifically cleaved to activate the prodrug in a phagocytic mammalian cell infected with a microorganism. A microparticle linked antimicrobial drug or prodrug may be used for killing a microorganism infecting a phagocytic mammalian cell in vivo or in vitro.
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Gallicchio Vincent S.
Meredith Michael J.
Stowell Michael H B
Yatvin Milton B.
Naff David M.
Oregon Health & Sciences University
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