Conjugate of an antibody against CCR5 and an antifusogenic...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S178100, C530S391700

Reexamination Certificate

active

07951920

ABSTRACT:
The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of the anti-CCR5 antibody and to the pharmaceutical use of the conjugate.

REFERENCES:
patent: 5202238 (1993-04-01), Fell et al.
patent: 5204244 (1993-04-01), Fell et al.
patent: 5464933 (1995-11-01), Bolognesi et al.
patent: 5656480 (1997-08-01), Wild et al.
patent: 5871732 (1999-02-01), Burkly et al.
patent: 5876969 (1999-03-01), Fleer et al.
patent: 6013263 (2000-01-01), Barney et al.
patent: 6017536 (2000-01-01), Barney et al.
patent: 6060065 (2000-05-01), Barney et al.
patent: 6093794 (2000-07-01), Barney et al.
patent: 6136310 (2000-10-01), Hanna et al.
patent: 6258782 (2001-07-01), Barney et al.
patent: 6348568 (2002-02-01), Barney et al.
patent: 6479055 (2002-11-01), Bolognesi et al.
patent: 6528625 (2003-03-01), Wu et al.
patent: 6610834 (2003-08-01), Lobo
patent: 6656906 (2003-12-01), Barney et al.
patent: 7138496 (2006-11-01), Hua et al.
patent: 2001/0000241 (2001-04-01), Li et al.
patent: 2002/0048786 (2002-04-01), Rosen et al.
patent: 2002/0061834 (2002-05-01), Rosen et al.
patent: 2002/0106374 (2002-08-01), Olson et al.
patent: 2002/0146415 (2002-10-01), Olson et al.
patent: 2002/0147147 (2002-10-01), Molling et al.
patent: 2002/0147311 (2002-10-01), Gillies et al.
patent: 2003/0003440 (2003-01-01), Lopalco
patent: 2003/0044411 (2003-03-01), Olson et al.
patent: 2003/0049227 (2003-03-01), Gillies et al.
patent: 2003/0049251 (2003-03-01), Barbas et al.
patent: 2003/0099645 (2003-05-01), Lobo
patent: 2003/0100058 (2003-05-01), Roschke et al.
patent: 2003/0103984 (2003-06-01), Kohler
patent: 2003/0104581 (2003-06-01), Hoess et al.
patent: 2003/0152913 (2003-08-01), Hua et al.
patent: 2003/0165988 (2003-09-01), Hua et al.
patent: 2003/0166024 (2003-09-01), Rosen et al.
patent: 2003/0166870 (2003-09-01), Wu et al.
patent: 2003/0195348 (2003-10-01), Combadiere et al.
patent: 2003/0215421 (2003-11-01), McDonald et al.
patent: 2003/0226155 (2003-12-01), Sadeghi et al.
patent: 2003/0228306 (2003-12-01), Olson et al.
patent: 2004/0043033 (2004-03-01), Green
patent: 2005/0008649 (2005-01-01), Shin et al.
patent: 2005/0100991 (2005-05-01), Rosen et al.
patent: 2005/0114037 (2005-05-01), Desjarlais et al.
patent: 2006/0051346 (2006-03-01), Wijdenes
patent: 2006/0121480 (2006-06-01), Fung
patent: 2007/0036796 (2007-02-01), Brandt et al.
patent: 0 512 112 (1991-11-01), None
patent: 0 307 434 (1993-09-01), None
patent: 0 512 112 (1997-05-01), None
patent: 0 442 724 (1999-10-01), None
patent: 1 207 202 (2002-05-01), None
patent: 0 840 618 (2003-04-01), None
patent: 1 161 456 (2004-12-01), None
patent: 1 266 965 (2006-05-01), None
patent: 0 854 885 (2006-12-01), None
patent: 1 346 731 (2006-12-01), None
patent: 1 144 006 (2007-10-01), None
patent: WO 91/09966 (1991-07-01), None
patent: WO 92/09305 (1992-06-01), None
patent: WO 94/26910 (1994-11-01), None
patent: WO 96/40191 (1996-12-01), None
patent: WO 97/46697 (1997-12-01), None
patent: WO 98/33523 (1998-08-01), None
patent: WO 98/52976 (1998-11-01), None
patent: WO 99/59615 (1999-11-01), None
patent: WO 00/34317 (2000-06-01), None
patent: WO 00/69902 (2000-11-01), None
patent: WO 01/42308 (2001-06-01), None
patent: WO 01/43779 (2001-06-01), None
patent: WO 01/58915 (2001-08-01), None
patent: WO 01/58916 (2001-08-01), None
patent: WO 02/22077 (2002-03-01), None
patent: WO 02/083172 (2002-10-01), None
patent: WO 03/033666 (2003-04-01), None
patent: WO 03/066830 (2003-08-01), None
patent: WO 03/072766 (2003-09-01), None
patent: WO 2004/029074 (2004-04-01), None
patent: WO 2004/085505 (2004-10-01), None
patent: WO 2004/101739 (2004-11-01), None
patent: WO 2004/103312 (2004-12-01), None
patent: WO 2004/108885 (2004-12-01), None
patent: WO 2005/067960 (2005-07-01), None
patent: WO 2006/103100 (2006-10-01), None
patent: WO 2007/045463 (2007-04-01), None
patent: WO 2007/045465 (2007-04-01), None
Rudikoff, Giusti, Cook, and Scharff. Single amino acid substitution altering antigen binding specificity. Proceedings of the National Academy of Sciences, 1982. vol. 79, pp. 1979-1893.
Mac Callum, Martin, and Thronton. Antibody-antigen interactions: contact analysis and binding site topography. Journal of Molecular Biology, 1996. vol. 262, pp. 732-745.
De Pascalis, Iwahashi, Tamura, Padlan, Gonzales, Santos, Giuliano, Schuck, Schlom, and Kashmiri. Grafting of abbreviated complementarity determining regions containing specificity determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody. Journal of Immunology, 2002. vol. 169, pp. 3076-3084.
Casset, Roux, Mouchet, Bes, Chardes, Granier, Mani, Pugniere, Laune, Pau, Kaczorek, Lahana, and Rees. A peptide mimetic of an anti-CD4 monoclonal antibody by rational design. Biochemcial and Biophysical Research Communications, 2003. vol. 307, pp. 198-205.
Vajdos, Adams, Breece, Presta, De Vos, and Sidhu. Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis. Journal of Molecular Biology, 2002. vol. 320, pp. 415-428.
Holm, Jafari, and Sundstrom. Functional mapping and single chain construction of the anti-cytokeratin 8 monoclonal antibody TS1. Molecular Immunology, 2007. vol. 44, pp. 1075-1084.
Chen, Wiesmann, Fuh, Li, Christinger, McKay, De Vos, and Lowman. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. Journal of Molecular Biology, 1999. vol. 293, pp. 865-881.
Wu, Nie, Huse, and Watkins. Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues. Journal of Molecular Biology, 1999. vol. 294, pp. 151-162.
Wang, L.X. et. al., “Carbohydrate-Centered Maleimide Cluster as a New Type of Templates for Multivalent Peptide Assembling: Synthesis of Multivalent HIV-1 gp41 Peptides,”Bioorganic&Medicinal Chem. (2003) vol. 11, Issue 1, pp. 159-166.
Wild, C. et al., “Propensity for a Leucine Zipper-like Domain of Human Immunodeficiency Virus Type 1 gp41 to Form Oligomers Correlates with a Role in Virus-induced fusion rather than assembly of the Glycoprotein Complex,”Proc. Natl. Acad. Sci. (1994) vol. 91, pp. 12676-12680.
Bar, S. et. al. “Role of the Ectodomain of the gp41 Transmembrane Envelope Protein of Human Immunodeficiency Virus type 1 in late Steps of the Membrane Fusion Process,”J. Virology, 2004, vol. 78 (2), pp. 811-820.
Brady, et. al. “The Structure of CD4,”Curr. Topic Microbiol. Immunol. 1996, vol. 205, pp. 1-17.
Brenneman, et. al. “Acquired Immune Deficiency Syndrome and the Developing Nervous System,”International Rev. Neurobiology, 1990, vol. 32, pp. 305-353.
Brunhouse, R., et al.,“Isotypes of IgG: Comparison of the Primary Stuctures of Three Pairs of Isotypes which Differ in their Ability to Activate complement,”Molecular Immunology. 16 (1979) 907-917.
Burnette, “Western Blotting: Electrophoretic Transfer of Proteins from Sodium Dodecyl Sulfate-Polyacrylamide Gels to Unmodified Nitrocellulose and Radiographic Detection with Antibody and Radioiodinated Protein A,”Analytical Biochem. 1981, vol. 112, pp. 195-203.
Burton, D.R. et. al., “The C1q Receptor Site on Immunoglobulin G,”Nature(1980) vol. 288, pp. 338-344.
Cohen, J. “Likely HIV Cofactor Found,”Science1996, vol. 272, pp. 809-810.
Cocchi, F. et. al., “Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8+ T Cells,” Science (1995) vol. 270 pp. 1811-1815.
Dean, M., et al., “Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene,”Science273 (1996) 1856-1862.
Edelman, G.M., et al., “The Covalent Structure of an Entire—G Immunoglobin Molecule,”Natl. Acad. Sci. USA63 (1969

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