Conjugate having cytotoxicity and process for the preparation th

Details Conjugate having cytotoxicity and process for the preparation th Conjugate having cytotoxicity and process for the preparation th

1983-12-21

1985-09-24

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424 85, 525 541, 514 12, C07G 700, C07C10352, A61K 3944, A61K 39395

Patent

active

045432112

ABSTRACT:
A conjugate having cytotoxicity prepared by covalently binding a polymer which has cytotoxic substances linked to its side chains and a reactive group at its terminal to an immunoglobulin, or its fragment, which is capable of selectively binding to a particular antigen possessed by cells to be killed.

REFERENCES:
patent: 4017471 (1977-04-01), Davies
patent: 4046722 (1977-09-01), Rowland
patent: 4093607 (1978-06-01), Sela et al.
patent: 4263279 (1981-04-01), Sela et al.
patent: 4315851 (1982-02-01), Yoshikumi et al.
patent: 4340535 (1982-07-01), Voisin et al.
patent: 4350626 (1982-09-01), Masuho et al.
patent: 4363758 (1982-12-01), Masuho et al.
patent: 4368149 (1983-01-01), Masuho et al.
patent: 4379145 (1983-04-01), Masuho et al.
patent: 4401592 (1983-08-01), Yoshikumi et al.
Nature, vol. 271, Feb. 1978, pp. 752-754, Thorpe et al.

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