Conjugate having a cleavable linkage for use in a liposome

Details Conjugate having a cleavable linkage for use in a liposome Conjugate having a cleavable linkage for use in a liposome

2006-01-10

2006-01-10

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C514S506000, C514S767000, C514S768000, C554S078000, C554S079000, C554S080000, C554S081000, C554S085000, C564S341000

Reexamination Certificate

active

06984396

ABSTRACT:
Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The linkage is stable under nonreducing conditions. The conjugate can be incorporated into liposomes for administration in vivo and release of the therapeutic agent in response to endogeneous in vivo reducing conditions or in response to administration of an exogeneous reducing agent.

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