Conjugate for treating inflammatory diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514152, 514183, 514249, A61K 3838, A61K 3840, A61K 3165, A61K 3133, A61K 3150

Patent

active

059069775

DESCRIPTION:

BRIEF SUMMARY
I. FIELD OF THE INVENTION

The present invention relates to the use of conjugates comprising an active substance, a linker and a carrier, for treating and/or diagnosing inflammatory diseases.


II. BACKGROUND OF THE INVENTION

For treating inflammatory diseases such as infectious and/or autoimmune and/or skin diseases, pharmaceutical preparations which have to be administered in very high doses have been used so far. This represents a major load for the liver. In addition, these pharmaceutical preparations concentrate in many tissues which represents a further load for the body.
DE-A 39 12 792 and DE-A-40 17 439 disclose conjugates of the above kind which can be used for treating and/or diagnosing tumors.
Surprisingly, it has not been found that these conjugates are also suitable for treating and/or diagnosing inflammatory diseases such as infectious and/or autoimmune and/or skin diseases and/or inflammatory neovascularizations, e.g., in the cornea of the eye, without being accompanied by the drawbacks of the pharmaceutical preparations used for this purpose so far.
Thus, the above conjugates are used according to the invention for the treating and/or diagnosing inflammatory diseases such as infectious and/or autoimmune and/or skin diseases, such as psoriasis, and/or inflammatory neovascularizations, e.g., in the cornea of the eye.


III. SUMMARY OF THE INVENTION

The present invention relates pharmaceutical compositions comprising a conjugate of an active substance, a linker and a carrier for the treatment and/or diagnosis of inflammatory diseases. The present invention further relates to methods using such pharmaceutical compositions for treating and diagnosing of inflammatory diseases including, but not limited to, infectious diseases, autoimmune diseases, skin diseases, and inflammatory neovascularization.


IV. BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the linkage of radioactively labeled tyramine-N-1'-deoxysorbitol (TDS) to albumin via cyanuric chloride,
FIG. 2 shows the linkage of tetracarboxyphenylporphyrin (TCPP) to albumin,
FIG. 3 shows the linkage of tetrahydroxyphenylporphyrin (THOPP) to methoxypolyethylene glycol (MPEG) via cyanuric chloride, and
FIG. 4 shows the concentration of conjugates in inflammatory tissue.


V. DETAILED DESCRIPTION OF THE INVENTION

The expression "active substance" comprises compounds of any kind which can be used for treating and/or diagnosing inflammatory diseases, particularly infectious and/or autoimmune and/or skin diseases and/or inflammatory neovascularizations. Examples of the above compounds are radioactively labeled aromatic compounds, photodynamically active compounds and chemotherapeutic agents. Examples of photodynamically active compounds are porphyrin derivatives such as tetracarboxyphenylporphyrin (TCPP) and tetrahydroxyphenylporphyrin (THOPP), chlorines and bacteriochlorines. Examples of chemotherapeutic agents are cytostatic agents and antibiotics. Representatives thereof are, e.g., doxorubicin, daunorubicin, tetracycline and derivatives thereof as well as antimetabolites such as methotrexate. The above photodynamically active compounds and chemotherapeutic agents may also be labeled, e.g., by means of a radioactive substance such as iodine. In addition, a conjugate used according to the invention may not only contain a single but also several of the compounds.
The expression "linker" comprises compounds of any kind which are suitable for linking two components of the conjugate, particularly protein and active substance. Examples of such linkers are cyanuric chloride and derivatives thereof which are used as educt for forming the conjugate. Furthermore, a linker may already be part of the active substance, so that no further linker has to be incorporated into the conjugate. An example of this is given in FIG. 2.
The expression "carrier" comprises compounds of any kind which are suitable for concentrating the conjugate in a tissue damaged by an above disease. Examples thereof are proteins which are not considered exogenous and polyethylene glyco

REFERENCES:
patent: 4466951 (1984-08-01), Pittman
patent: 5308604 (1994-05-01), Sinn et al.
patent: 5382657 (1995-01-01), Karasiewicz et al.
patent: 5622685 (1997-04-01), Sinn et al.
Bartilini et al, Derwent World Patent Index File, abstract No. 92-142656, 92.
Hamblin et al., "Conjugates Between Proteins and Fluorescent Dyes as Potential Photosensitizers," Photodynamic Therapy and Biomedical Lasers, Proceedings of the International Conference on Photodynamic Therapy and Medical Laser Applications, Milan, Jun. 24-27, 1992, P. Spinelli, M. Dal Fante, R. Marchesini, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy, Excerpta Medica, Amsterdam-London-New York-Tokyo, pp. 169-173.
Maxwell et al., 1988, "Insulin-.sup.125 I-Tyramine, an Improved Residualizing Label for Studies on Sites of Catabolism of Circulating Proteins," Journal of Biological Chemistry 263(28):14122-14127.
Winkelman, James W., 1967, "Metabolic Studies on the Accumulation of Tetraphenylporphinesulfonate in Tumors," Experientia 23(11):949-50.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Conjugate for treating inflammatory diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conjugate for treating inflammatory diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugate for treating inflammatory diseases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-401360

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.