Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1986-05-13
1988-12-06
Brown, J. R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530402, 530403, 530405, 530806, 424 88, 424 92, 514 54, 514 23, 536 11, 536123, C07K 1504, A61K 3909
Patent
active
047897350
ABSTRACT:
The conjugate according to the invention is constituted by a wall adhesin of Streptococcus mutans, of a proteinic nature, capable of binding the components of saliva, or an active fraction of such a protein, covalently coupled to a Streptococcus mutans polysaccharide, or to a fraction of such a polysaccharide.
Preferably, the adhesin is constituted by a single polypeptide chain having a molecular weight of about 74,000; it is common to the different serotypes of Streptococcus mutans where it has a crossed antigenicity; and it is capable of interacting with the salivary glycoproteins and polysaccharide derived from the same serotype of S. mutans, particularly serotype f.
Use for the preparation of immunogenic compositions, particularly for the preparation of vaccines against dental caries.
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Bacterial Vaccine, ed., Germanier, 1984, Academic Press (see p. 250).
Makela, et al., Scand. J. Immunol, 19, 1984, pp. 541-550.
Taubman, et al., J. Dental Res. 60, 1981, p. 634 (#1298).
Wachsmann, et al., Infect & Immunity, 52, 1986, pp. 408-413.
Bruyere, et al., Vaccines, 5, 1987, pp. 39-42.
Ackermans Fabienne
Bazin Herve
Frank Robert
Klein Jean P.
Brown J. R.
Draper Garnette D.
Institut National de la Sante et de la Recherche Medicale
Universite Catholique de Louvain
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