Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-05-26
1997-11-04
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 5303913, 5303915, 5303919, 530402, 540465, 540474, C07K 1706
Patent
active
056841353
ABSTRACT:
##STR1## Conjugate compounds are described comprising a compound of formula (1), wherein A is a group --Alk.sup.3 -- or --Alk.sup.3 N(R.sup.4)Alk.sup.1 --, Alk.sup.2, Alk.sup.3 and Alk.sup.4 which may be the same or different is each a C.sub.1-4 alkylene chain optionally substituted by one or more C.sub.1-6 alkyl groups; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, is each a hydrogen atom or a group--AlkR.sup.5 where Alk is an optionally substituted straight or branched C.sub.1-6 alkyl group and R.sup.5 is a hydrogen atom or a --CO.sub.2 H, --CONR.sup.6 R.sup.7 (where R.sup.6 and R.sup.7, which may be the same or different is each a hydrogen atom or an alkyl group) or --P(X.sup.1)(X.sup.2 R.sup.8)L group where X.sup.1 and X.sup.2 is each an oxygen or sulphur atom. R.sup.8 is a hydrogen atom or an alkyl group and L is an aliphatic, aromatic, or heteroaromatic group or a linker group with the proviso that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a group AlkP(X.sup.1)(X.sup.2 R.sup.8)L where L is a linker group; and a metal complexes and/or salts thereof, coupled to a protein, peptide or carbohydrate. The conjugates are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours.
REFERENCES:
patent: 4174319 (1979-11-01), Kobuke
patent: 4174428 (1979-11-01), Tabushi et al.
patent: 4432907 (1984-02-01), Wieder et al.
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4678667 (1987-07-01), Meares
patent: 4877600 (1989-10-01), Bonnemain et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 5045451 (1991-09-01), Uhr et al.
patent: 5049667 (1991-09-01), Schaefer et al.
patent: 5053503 (1991-10-01), Dean et al.
Moi, C.F., et al., J. Am. Chem. Soc., 110, 6266 (1988).
Khaw et al., Science. 209, 295 (1980).
Krejcarek et al., Biochem. Biophys. Res. Comm., 77, 581 (1977).
Childs, R.L. and Hnatowich, D.J., J. Nuc. Med. 26, 293 (1985).
Stetter, H., et al., Angew. Chem. Int. Ed. Engl., 15, 686 (1976).
Loncin, J.F., et al., Inorg. Chem., 25, 2646 (1986).
Tweedle, M.F., et al., J. Nuc. Med., 28, 705 (1988).
Goodwin, C.H., et al., J. Nuc. Med., 27, 959 (1986).
Paik, C.H., et al., J. Nuc. Med., 28, 572 (1987).
Paik, C.H., et al., J. Nuc. Med., 29, 889 (1988).
Haseman, C.F., et al., Eur. J. Nuc. Med., 12, 455 (1986).
Parker et al., Pure & Appl. Chem., vol. 61, No. 9, 1637-1641 (1989).
Craig et al., J. Chem. Soc. Chem. Commun. (1989), pp. 794-796.
Cox et al., J. Chem. Soc. Chem. Commun. (1989), pp. 797-798.
Paik et al., J. Nucl. Sci., vol. 30, No. 10, p. 1693-1701 (Nov./1989).
Paik et al., Nucl. Med. Biol., vol. 16, No. 5, pp. 475-481 (1989).
Deshpande et al., Nucl. Med. Biol., vol. 16, No. 6, pp. 587-597 (1989).
Deshpande et al., The Journal of Nuclear Medicine. "Copper-67-Labeled Monoclonal Antibody Lym-1, A Potential Radio-pharmaceutical for Cancer Therapy: Labeling and Biodistribution in RAJI Tumored Mice", vol. 29, No. 2, pp. 217-225 (Feb. 1988).
Franz, J., et al., Abstract from Journal of Nuclear Medicine, Abstract No. 553, vol. 26, No. 5 (May 1985).
Meares, Claude F., Protein Tailoring for Food and Medicine Uses edited by R.E. Feeny et al., Attaching Metal Ions to Antibodies, pp. 339-352 (1986).
Goodwin, D.A., et al., Abstract of "In Complex of a New Macrocyclic Bifunctional Chelator TETA", presented at European Nuclear Medicine Congress Meeting at Barbican, London, No. 113 Sep. 3-6 (1985).
Meares et al., Int. J. Cancer Suppl., 2, 99-102 (1988).
Meares et al., Br. J. Cancer, 62, 21-26 (1990).
Gransow et al., ACS Symposium Series, No. 241, "Generator Produced Bi-212"(1984).
Moi et al., Anal. Biochem., 148, 249-253 (1985).
Broan et al., J. Chem. Soc. Chem. Commun. pp. 1739-1741 (Dec. 1, 1990).
Broan et al., J. Chem Soc Chem Commun pp. 1738-1739 (Dec. 1, 1990).
Kabachnik et al., Bull Acad Sci USSR DIV Chem Sci vol. 33, No. 4, Part I, pp. 769-777 (1984).
Kabachnik et al., Bull Acad Sci USSR DIV Chem Sci vol. 33, No. 4, pp. 777-782 (1984).
Yatsimirrskii et al., Chem. Abstr. vol. 100, No. 198535c 1984.
Beeley Nigel Robert Arnold
Millican Thomas Andrew
Parker David
Celltech Therapeutics Limited
Chan Christina Y.
Ponnaluri Padmashri
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