Conjugate and method for forming aminomethyl phosphorus conjugat

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

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424 177, 424 111, 424 145, 424 149, 424 169, 568 8, A61K 5100, A61M 3614

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059483865

ABSTRACT:
A method of forming phosphine-amine conjugates includes reacting a hydroxymethyl phosphine group of an amine-free first molecule with at least one free amine group of a second molecule to covalently bond the first molecule with the second molecule through an aminomethyl phosphorus linkage and the conjugates formed thereby.

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