Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-11-22
2005-11-22
Ceperley, Mary E. (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C435S007930, C435S007950, C435S188000, C436S161000, C436S531000, C530S388900, C530S389800, C530S391100, C530S388400, C530S403000, C530S405000, C530S406000
Reexamination Certificate
active
06967240
ABSTRACT:
The present invention relates to a protienaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of toxins derived from various cyanobacteria, to a method for its production, to diagnostic kits and to an affinty matrix (e.g. for use in immunoaffinity columns, online detection and purifications devices) containing the proteinaceous compound as well as to methods for substantially decreasing the amount of a compound containing the group represented by formula (I) in fluids or for concentrating compounds, e.g. toxins, containing the group represented by formula (I) from fluids such as crude water samples, extracts of algae or other tissue samples, e.g. to determine toxin concentrations.
REFERENCES:
J. An et al, Toxicon 32(12): 1495-1507 (1994). Use of a colorimetric protein phosphatase inhibition assay and ELISA for the study of Microcystins and Nodularins.
X. Huang et al.: “Production and characterization of monoclonal antibodies against the blue-green algal toxin microcystin.” Abstracts of the General Meeting of the American Society For Microbiology, vol. 96, 1996, p. 380 XP000982157, USA. Abstract P-64.
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S. Nagata et al.: “Enzyme immunoassay for direct determination of microcystins in enviromental water.” Journal of AOAC International, vol. 80, No. 2, 1997, pp. 408-417, XP000982223, Arlington, VA, USA., abstract.
K. Rinehart et al.: “Nodularin, microcystin, and the configuration of Adda.” Journal of the American Chemical Society, vol. 110, No. 25, Dec. 7, 1988, pp. 8557-8558, XP002160425, Washington, D.C., USA.
J. Humphrey et al.: “Total synthesis of the serine-threonine phosphatase inhibitor microcystin-LA.” Journal of the American Chemical Society, vol. 118, No. 47, Nov. 27 1996, pp. 11759-11770, XP002160426, Washington, D.C., USA.
J. Metcalf et al.: “Production of novel polyclonal antibodies against the cyanobacterial toxin microcystin-LR and their application for the detection and quantification of microcystins and nodularin.” Water Research, vol. 34, No. 10, Jul. 2000, pp. 2761-2769, XP004203376, Amsterdam, Netherlands.
Aggen James B.
Chamberlin A. Richard
Dietrich Daniel R.
Fischer Werner
Garthwaite Ian
Ceperley Mary E.
Dietrich Daniel R.
New Zealand Agricultural Research Institute Limited
The Regent of the University of California
Weingarten Schurgin, Gagnebin & Lebovici LLP
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