Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1994-12-14
2000-02-01
Woodward, Michael P.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
530324, 530325, 530326, 530327, 530328, 530329, 530330, 514 11, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, A61K 3800, C07K 752
Patent
active
060204605
ABSTRACT:
Novel synthetic Arg-Gly-Asp-containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformational structure such as a helix, by providing an additional chemical structure such as an amide or an enantiomer of a naturally occuring amino acid, or by other methods. In particular, there is provided a cyclic peptide having increased affinity and selectivity for the vitronectin receptor over that of linear, Arg-Gly-Asp-containing synthetic peptides.
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Pierschbacher Michael D.
Ruoslahti Erkki I.
La Jolla Cancer Research Foundation
Woodward Michael P.
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