Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-10-03
1998-03-24
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514270, 514401, 514402, 548190, 548193, 548233, 5483265, A61K 31425
Patent
active
057313377
ABSTRACT:
A compound of formula I ##STR1## in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or sulfur; R is hydrogen, lower straight or branched chain alkyl of 1 to 6 carbon atoms, or lower straight or branched chain alkenyl of 2 to 6 carbon atoms, a cycloaliphatic ring of 3 to 6 carbon atoms, phenyl optionally mono- or di-substituted with hydroxy, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 2 carbon atoms, or methylenedioxyphenyl; or a stereoisomer, or a pharmaceutically acceptable salt thereof.
These compounds have .alpha..sub.2 receptor blocking activity and hence find use in the treatment or palliation of elevated intraocular pressure, non insulin-dependent diabetes, male impotence and obesity.
REFERENCES:
patent: 2870159 (1959-01-01), Bloom
patent: 2876232 (1959-03-01), Bloom
patent: 3278382 (1966-10-01), Poos
patent: 3432600 (1969-03-01), Harvey, Jr.
patent: 3453284 (1969-07-01), Harvey, Jr.
patent: 3509170 (1970-04-01), Leavitt
patent: 3514486 (1970-05-01), Hartzler
patent: 3598833 (1971-08-01), Hiltmann
patent: 3624092 (1971-11-01), Levitt
patent: 3636219 (1972-01-01), Culik
patent: 3679798 (1972-07-01), Culik et al.
patent: 4064348 (1977-12-01), Peet et al.
patent: 4256755 (1981-03-01), Smith
patent: 4515800 (1985-05-01), Cavero et al.
patent: 4587257 (1986-05-01), De Santis et al.
patent: 4590202 (1986-05-01), Remy
patent: 4980364 (1990-12-01), Goodman
patent: 5066664 (1991-11-01), Gluchowski
patent: 5091528 (1992-02-01), Gluchowski
patent: 5580892 (1996-12-01), Garst
Registry No. 101832-33-1 (1986).
Poos, et al, Journal of Organic Chemistry, 1961, 26, 4898-4904, "Bicyclic Bases.III. Isomeric 2-Amino-3-phenylnorbornanes.sup.1 ".
Burke James A.
Garst Michael E.
Munk Stephen A.
Allergan
Baran Robert J.
Daus Donald G.
Hoch James M.
Voet Martin A.
LandOfFree
Conformationally rigid bicycle and adamantane derivatives useful does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Conformationally rigid bicycle and adamantane derivatives useful, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conformationally rigid bicycle and adamantane derivatives useful will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2289256