Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-10-15
1999-03-30
Burn, Brian M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
564509, 564510, A61K 3113
Patent
active
058890610
ABSTRACT:
Compounds of Formula I:
REFERENCES:
Ashton, Wallace T.; Meurer, Laura Canning; Cantone, Christine L.; Field, A. Kirk; Hannah, John, Karkas, John D., Liou, Richard; Patel, Gool F.; Perry, Helen C.; Wagner, Arthur F.; Walton, Edward, and Tolman, Richard L., J. Med. Chem (1988) 31:2304.
Bergeron, R.J.; McManis, J.S.; Liu, C.Z.; Feng, Y.; Weinar, W.R.; Luchetta, G.R.; Wu, Q., Ortiz-Ocasio, J.; Vinson, J.R.T.; Kramer, D.; and Porter, C., J. Med. Chem. (1994), 37:3464-3476.
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Cerecedo, L.R., and Pickel, F.D., Studies on Pyrimidines: I. The Preparation of 2-Methyl-6-oxypyrimidine-5-acetic Acid and Some of its Derivatives, Contribution from the Chemistry Department, Fordham University (1937) 59:1714-1716.
Fabiano, E., Golding, B.T., and Sadeghi, M.M., Synthesis (1987), 190-192.
Insaf, S.S., Danks, M.K., and Witiak, D., A Structure-Function Analysis of DNA Topoisomerase II Inhibitors, Current Medicinal Chemistry, (1996) 3:437-466.
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Miller, A.E.G., Biss, J.N., and Schwartzman, L.H., J. Org. Chem. (1959), 24:627.
Nagarajan, S. and Ganem, B., Chemistry of Naturally Occurring Polyamines. II. Unsaturated Spermidine and Spermine Derivatives, J. Org. Chem. (1987), 52:5044-46.
Pegg, A.E., Nagarajan, S., Naficy, S., and Ganem, B., Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells, Biochem. J. (1991), 274:167-171 (Printed in Great Britain).
Pharmaceuticals, Chiral, Reprinted from Kirk-Othmer Encyclopedia of Chemical Technology, Fourth Edition, vol. 18, ISBN 0-471-52587-8 (1996) by John Wiley & Sons, Inc.
Smirnov, I., Tiffany, K., Jackson, V., and Basu, H., Effects of Spermine and Its Cytotoxic Analogs on Nucleosome Formation on Relaxed and Supercoiled DNA In Vitro, Biochemistry, (1995).
Frydman Benjamin J.
Marton Laurence J.
Reddy Vendohar K.
Valasinas Aldonia L.
Witiak Donald T.
Burn Brian M.
Wisconsin Alumni Research Foundation
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