Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Patent
1994-05-02
1995-12-12
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
A61K 3800, C07K 500, C07K 700, C07K 1700
Patent
active
054750857
ABSTRACT:
The invention provides materials and methods for synthesizing novel reverse turn mimetics, as well as peptides containing the same. Also provided are novel synthetic nonpeptide therapeutic molecules designed upon the interactions between reverse turn mimetics or peptides containing the same, and receptors, antibodies, or enzymes.
REFERENCES:
patent: 4699898 (1987-10-01), Gottlieb
patent: 4908203 (1990-03-01), Thornton
Chen et al., "Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes," Proc. Natl. Acad. Sci. USA 89:5872-5876, 1992.
Rajeswari et al., "A New Synthesis of Amides from Acyl Fluorides and n-Silylamines", Tetrahedron Letters 28(43):5099-5102, 1987.
Miller et al., J. Am. Chem. Society vol. 102 pp. 7026-7032 (1980).
Spatola, Chemistry & Biochemistry of Amino Avids, Peptides & Proteins, vol. VII, (Weinstein, Ed.) Marcel Dekker, New York (1983).
Friedinger, et al., Science 210: 656-658 (1980).
Vallee, et al., Int. J. Pept. Prot. Res. 33: 181-190 (1989).
Krstenansky, et al., Biochem. Biophys. Commun. 109: 1368-1374 (1982).
Kahn, et al. Tetrahedron Lett. 27: 4841-4844.
Kahn, et al. Hetrocycles 25: 29-31 (1987).
Kahn, et al. Tetrahedron Lett. 28: 1623-1626 (1987).
Kahn, et al., J. Am. Chem. Soc. 110: 1638-1639 (1983).
Kahn, et al., J. Mol. Recogn. 1: 75-79 (1988).
Kemp., et al., Tetrahedron Lett. 29: 5057-5060 (1988).
Arrenius, et al., Proc. Am. Peptide Symp., River & Marshall, Eds. Escon, Leiden (1990).
Hruby, et al., Biochem J. 268: 249-262 (1990).
Ball, et al., J. Mol. Recogn. 3: 55-64 (1990).
Morgan, et al., Ann. Res. Med. Chem. 24: 243-252 (1989).
Fauchere, Adv. Drug. Res. 15: 29-69 (1986).
Kahn, et al. Tetrahedron Lett. 30: 2317-2320 (1989).
Carpino, et al., J. Am. Chem. Soc. 112: 9651-9652 (1990).
Wasserman, et al., Tetrahedron Lett. 23: 465-68 (1982).
Gilon, et al., Biopolymens 31: 745-50 (1991).
Olson, et al., J. Am. Chem. Soc.; 112: 323-333 (1990).
Huff Sheela J.
Molecumetics Ltd.
Warden Jill
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