Conformationally restricted aromatic inhibitors of microsomal tr

Details Conformationally restricted aromatic inhibitors of microsomal tr Conformationally restricted aromatic inhibitors of microsomal tr

1996-12-17

1998-06-02

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544139, 544182, 544256, 544311, 544316, 546270, 546277, 546297, 546265, 546308, 546337, 548132, 548136, 548110, 548171, 548187, 548144, 548221, 5482644, 5483071, 5483241, 548507, 549 14, 549218, 549371, 549388, 549441, 558 83, 564153, 564155, 564172, C07D23516

Patent

active

057602468

ABSTRACT:
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2;
R.sup.x is H, alkyl, aryl or halogen;
A is

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