Conformationally locked nucleosides and oligonucleotides

Details Conformationally locked nucleosides and oligonucleotides Conformationally locked nucleosides and oligonucleotides

1999-05-11

2000-07-04

Elliott, George C.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

536 221, 536 231, 536 256, 435 911, C07H 2102, C07H 2104, C12P 1934

Patent

active

06083482&

ABSTRACT:
Conformationally restricted 3',5'-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C3' and C5' of nucleosides through a linker or linking molecule. The nucleoside bases may be modified or unmodified. The nucleosides can be used as oligonucleotide building blocks or as small molecule pharmaceutical ingredients.

REFERENCES:
Guangyi Wang, Conformationally locked nucleosides. Synthesis and stereochemical assignments of 3'-N,5'-C-bridged 3'-amino-3'-deoxythymidines. Tetrahedron Letters 40 (1999), pp. 6343-6346, Oct. 1999.

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