Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen bonded directly to ring carbon of the purine ring...
Patent
1997-03-14
1999-02-09
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen bonded directly to ring carbon of the purine ring...
544277, 544314, 544317, C07D47318, C07D47334, C07D23954, C07D23947
Patent
active
058696660
ABSTRACT:
Conformationally locked 4',6'-cyclopropane-fused carboxylic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine, and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.
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Barchi, Jr. Joseph J.
Marquez Victor E.
Nicklaus Marc C.
Rodriguez Juan B.
Siddiqui Maqbool A.
Berch Mark L.
The United States of America as represented by the Secretary of
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