Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1994-09-23
1997-05-13
Bernhardt, Emily
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
568660, 568665, 568667, 568323, 568324, 544243, 544244, 544276, 544277, 544314, 544317, 544264, 536 221, 536 231, 536 2612, 536 2613, 536 2614, C07C 49172, C07C 43196, C07C 4106, C07D47318
Patent
active
056294549
ABSTRACT:
Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.
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Barchi, Jr. Joseph J.
Marquez Victor E.
Nicklaus Marc C.
Rodriguez Juan B.
Siddiqui Maqbool A.
Bernhardt Emily
The United States of America as represented by the Department of
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