Conformationally constrained parthyroid hormone (PTH) analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S013800, C514S014800, C514S015800, C530S326000, C530S327000, C530S328000

Reexamination Certificate

active

07910544

ABSTRACT:
The invention provides novel P1R polypeptide antagonists. These antagonists contain amino acid substitutions at selected positions in truncated PTH and PRHrP polypeptides and function by binding selectively to the juxtamembrane (“J”) domain of the receptor. The J domain is the region of the receptor that spans the seven transmembrane domain and the extracellular loops.

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