Conformationally constrained parthyroid hormone (PTH) analogs

Details Conformationally constrained parthyroid hormone (PTH) analogs Conformationally constrained parthyroid hormone (PTH) analogs

2011-03-22

2011-03-22

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C514S014800, C514S015800, C530S326000, C530S327000, C530S328000

Reexamination Certificate

active

07910544

ABSTRACT:
The invention provides novel P1R polypeptide antagonists. These antagonists contain amino acid substitutions at selected positions in truncated PTH and PRHrP polypeptides and function by binding selectively to the juxtamembrane (“J”) domain of the receptor. The J domain is the region of the receptor that spans the seven transmembrane domain and the extracellular loops.

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