Conformationally constrained LH-RH analogues, their uses and pha

Details Conformationally constrained LH-RH analogues, their uses and pha Conformationally constrained LH-RH analogues, their uses and pha

1999-05-24

2000-11-28

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 16, 530313, 530332, 930130, A61K 3809, C07K 723

Patent

active

061535877

ABSTRACT:
LH-RH analogues with excellent affinity for LH-RH receptors, of the formula A.sub.1 -A.sub.2 -W-A.sub.3 -A.sub.4 -SPL-A.sub.5 -A.sub.6 -Pro-Z(I) in which:

REFERENCES:
Freidinger et al, "Bioactive Conformation of Luteinizing . . . Analog" Science, vol. 210, 1980, pp. 656-658 (XP 000670105).
Ward et al, "Potent and Highly Selective Neurokinin Antagonists" Jour. of Medic. Chem., vol. 33, No. 7, 1990, pp. 1848-1851 (XP 002029055).
Hinds et al, "Design and Synthesis . . . Beta-Turn Mimetic", J. Chem. Soc. No. 22, 1988, pp. 1447-1449 (XP 002029056).
Hinds et al, Synthesis, Conformational Properties . . . Derivatives: J. Med. Chem., vol. 34, 1991, pp. 1777-1789 (XP 0020229057).
Chalmers et al, "Pro-D-NMe-Amino Acid . . . Reverse-Turn Constraints" J. Am Chem. Soc, vol. 117, 1995, pp. 5927-5937 (XP 002029058).

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