Conformationally constrained diacylglycerol analogues

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514372, 514424, 514439, 514471, 549 40, 549321, 549323, 548214, 548550, 548551, A61K 3134, C07D30734

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active

058744649

ABSTRACT:
Conformationally constrained diacylglycerol analogues, pharmaceutical compositions comprising such analogues, and methods of using such analogues as agonists and antagonists of protein kinase C.

REFERENCES:
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Sharma et al., "4-Bis(Hydroxymethyl)-4-Butanolide: A promising Template For The Construction Of Conformationally Constrained Diacylglycerols," Abstract 67, American Chemical Society, Division of Medicinal Chemistry, 207th ACS National Meeting, San Diego, CA, Mar. 13-17 (1994).
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