Conformationally constrained cyclic enkephalin analogs with delt

Details Conformationally constrained cyclic enkephalin analogs with delt Conformationally constrained cyclic enkephalin analogs with delt

1983-05-16

1985-05-21

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514809, 2601125E, A61K 3700, C07C10352

Patent

active

045187118

ABSTRACT:
Novel compounds which are capable of binding with enhanced specificity to the delta receptor are disclosed. The compounds are a series of cyclic, conformationally constrained analogs of enkephalins which display exceptional delta receptor specificity. The compounds of the present invention are polypeptides of the formula: ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, methyl, or lower alkyl having 1 to 5 carbon atoms;

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