Conformationally constrained analogs useful as antidiabetic...

Details Conformationally constrained analogs useful as antidiabetic... Conformationally constrained analogs useful as antidiabetic...

2006-04-19

2008-11-18

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S318000, C546S194000, C546S208000, C546S209000, C546S210000, C546S211000

Reexamination Certificate

active

07452907

ABSTRACT:
Compounds are provided which have the structurewherein Q is C or N, X1is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2, X3and X4are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

REFERENCES:
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patent: WO 01/38325 (2000-11-01), None
patent: WO 01/21602 (2001-03-01), None
Davis, Franklin A., et al., Organic Letters, 2001, vol. 3, No. 5, 759-762.
Swarbrick, Martin E., J. Org. Chem. 1999, 64, 1993-2002.
Jeff E. Cobb, et al., “N-(2-Benzoylphenyl)-L-tyrosine PPARy Agonist 3 Structure-Activity Relationship and Optimizaton of the N-Aryl Substituent”, J. Med. Chem., 1998, 41, 5055-5069.

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