Conformationally constrained alpha-melanotropin analogs with spe

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence

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C07K 706

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active

046491910

ABSTRACT:
Novel compounds which are analogs of .alpha.-melanotropin and which exhibit reactivity for the central nervous system receptors without exhibiting substantial reactivity for the peripheral receptors are disclosed. The compounds of the present invention are polypeptides of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted aromatic radical;

REFERENCES:
Knittel et al., Journal of Medicinal Chemistry, 28, 125-129 (1983).
Sawyer et al., Journal of Medicinal Chemistry, 25, 1022-1027 (1982).
Sawyer et al., Proc. Natl. Acad. Sci., USA, 79, 1751-55 (1982).
Chemical Abstracts, 101, 74 (1984), Abst. No. 66177X.
Chemical Abstracts, 97, 102 (1982), Abst. No. 17366Z.

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