Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-09
2006-05-09
Tate, Christopher R. (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S328000, C435S007210, C435S326000, C536S023500, C530S387300, C424S133100
Reexamination Certificate
active
07041462
ABSTRACT:
Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.
REFERENCES:
patent: 0 861 900 (1998-09-01), None
patent: WO 96/08561 (1996-03-01), None
Song et al.Cell100:333-343 (2000).
Wiertz et al.Nature384:432-438 (1996).
Sidrauski et al.Trends Cell Biol8:245-249 (1998).
Ellgard et al.Science286:1882-1888 (1999).
AnfinsenScience181:223-230 (1973).
Ellis et al.Faseb J.10:20-26 (1996).
Dill et al.Nature Struct Biol4:10 (1997).
BlobelPNAS77:1496-1500 (1980).
Gorlich et al.Cell75:615-630 (1993).
Jungnickel et al.Cell82:261-270 (1996).
Skach et al.J. Biol Chem268:23552-23561 (1993).
Borel et al.Cell85:379-389 (1996).
Heinrich et al.Cell102:233-244 (2000).
Moss et al.Mol Biol Cell9:2681-2697 (1998).
Matlack et al.J. Cell Biol270:6170-6180 (1999).
Lyko et al.J Biol Chem270:19873-19878 (1995).
Rapoport et al.J Biol Chem.380:1143-1150 (1999).
Liu et al.PNAS86:9213-9217 (1986).
Chen et al.Mol Biol Cell11:765-772 (2000).
Hedge et al.Science279:827-834 (1988).
Voigt et al.J Cell Biol134:25-35 (1996).
Lopez et al.Science248:226-229 (1990).
Hedge et al.Mol Cell2:85-91 (1998).
Wolin et al.J Cell Biol109:2617-2622 (1989).
Hedge et al.Cell85:217-228 (1996).
Wickner et al.Science286:1888-1893 (1999).
Ibba et al.Science286:1893-1897 (1999).
Hedge et al. “Transmissible and genetic prion diseases share a common pathway of neurodegeneration”Nature402:822-826 (1999).
Hoelscher et al. “Prion protein contains a second endoplasmic reticulum targeting signal sequence located at its C terminus”J Biol Chem276:13388-13394 (2001).
Eble et al. “Multiple topogenic sequences determine the transmembrane orientation of hepatitis B surface antigen”Mol cell Biol7:3591-3601 (1987).
Bhagwat et al.J Biol Chem274:24014-24022 (1999).
Skach et al.J Biol Chem2681):6903-6908 (1993).
Hegde Ramanujan S.
Lingappa Vishwanath R.
Rutkowski D. Thomas
Chism B. Dell
Foley & Lardner LLP
Regents of the University of California
Tate Christopher R.
LandOfFree
Conformational and topological protein regulation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Conformational and topological protein regulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conformational and topological protein regulation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3649958