Data processing: structural design – modeling – simulation – and em – Modeling by mathematical expression
Reexamination Certificate
2007-04-03
2007-04-03
Moran, Marjorie A. (Department: 1631)
Data processing: structural design, modeling, simulation, and em
Modeling by mathematical expression
C703S011000, C702S019000
Reexamination Certificate
active
10223234
ABSTRACT:
The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and charge characteristics of the oligonucleotides. Biological activities include, but are not limited to, cellular proliferation, induction of cell cycle arrest and apoptosis.
REFERENCES:
patent: 5643890 (1997-07-01), Iversen et al.
patent: WO 01/44465 (2001-06-01), None
Bates, P., et al., Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding,J. Biol. Chem., vol. 274, No. 37, pp. 26369-26377 (1999).
Chen, H., et al., “Synthesis and Structure-activity Studies of a Series of [(Hydroxybenzyl)amino]Salicylates as Inhibitors of EGF Receptor-associated Tyrosine Kinase Activity”,J. Med. Chem., vol. 36, No. 25, pp. 4094-4098 (1993) (Abstract Only).
Dimri, G., et al., “A Biomarker that Identifies Senescent Human Cells in Culture and in Aging SkinIn Vivo”, Proc. Natl. Acad. Sci USA, vol. 92, pp. 9363-9367 (1995).
Evrard-Todeschi, N., et al., “Predictive Study by Molecular Modeling to Promote Specific Probes of Glutamate Receptors, Using Methylated Cyclic Glutamic Acid Derivatives (trans-and cis-ACPD). Comparison with Specific Agonists.”,J. Chem. Inf. Comput. Sci., vol. 38, No. 4, pp. 742-760 (1998) (Abstract Only).
Filion, M., et al., “Pro-apoptotic and Terminal Differentiation Activity of 6 Base Length Phosphodiester Oligonucleotide, Oligomodulator™ BT 99-25, Towards Leukemia Cells”, Program and Abstracts of the 6thInternational Symposium held at L'Institut Pasteur, Paris, France, No. 155 (Oral Session 1092), p. S-93 (2002).
Guarna, A., et al., “19-nor-10-azasteroids, a New Glass of Steroid 5 Alpha-reductase Inhibitors, 2. X-ray Structure, Molecular Modeling, Conformational Analysis of 19-nor-10-azasteroids and Comparison with 4-azasteroids and 6-azasteroids”,J. Med. Chem., vol. 40, No. 21, pp. 3466-3477 (1997) (Abstract Only).
Hochhauser, D., “Modulation of Chemosensitivity Through Altered Expresion of Cell Cycle Regulatory Genes in Cancer”,Anticancer Drugs, vol. 8, No. 10, pp. 903-910 (1997) (Abstract Only).
Koopman, G. et al., “Annexin V for Flow Cytometric Detection of Phosphatidylserine Expression on B Cells Undergoing Apoptosis”,Blood, vol. 84, No. 5, pp. 1415-1420 (1994) (Abstract Only).
Mata, J. et al., “A Hexameric Phosphorothioate Oligonucleotide Telomerase Inhibitor Arrests Growth of Burkitt's Lymphoma Cellsin Vitroandin Vivo”, Toxicol. Appl. Pharmacol., vol. 144, pp. 189-197 (1997).
Morassutti, C. et al., “Effect of Oligomer Length and Base Substitutions on the Cytotoxic Activity and Specific Nuclear Protein Recognition of GTn Oligonucleotides in the Human Leukemic CCRF-CEM Cell Line”,Nucleosides&Nucleotides, vol. 18, Nos. 6 & 7, pp. 1711-1716 (1999).
Read, M. et al., “Structure-based Design of Selective and Potent G Quadruplex-mediated Telomerase Inhibitors”,Proc. Natl. Acad. Sci. USA, vol. 98, No. 9, pp. 4844-4849 (2001).
Scaggiante, B., et al., Human Cancer Cell Lines Growth Inhibition by GTnOligodeoxyribonucleotides Recognizing Single-stranded DNA-binding Proteins,Eur. J. Biochem., vol. 252, pp. 207-215 (1998).
Vlassov, V., et al., “Transport of Oligonucleotides Across Natural and Model Membranes”,Biochim. Biophys. Acta, vol. 1197, No. 2, pp. 95-108 (1994).
Wagner, R., “Gene Inhibition Using Antisense Oligodeoxynucleotides”,Nature, vol. 372, pp. 333-335 (1994).
Kandimalla, E. R., et al., “Effect of Chemical Modifications of Cytosine and Guanine in a CpG-Motif of Oligonucleotides: Structure-immunostimulatory Activity Relationships”, Bioorganic & Medicinal Chemistry, vol. 9, pp. 807-813 (2001).
Reader, S., et al., “Identification of Non-Antisense Phosphodiester Oligonucleotides that Induce Cell Cycle Arrest and Apoptosis in Cancer Cells”, Clinical Cancer Research, The American Association for Cancer Research, vol. 6, p. 526, (2000).
International Search Report issued in International Patent Application No. PCT/IB02/03324, mailed Apr. 16, 2004.
Filion Mario C.
Holan Zdenek Richard
Phillips Nigel C.
Reader Stéphanie
Bionicrie Life Sciences, Inc.
Kilpatrick & Stockton LLP
Moran Marjorie A.
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