Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-07-01
2008-07-01
Haddad, Maher M (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S353000
Reexamination Certificate
active
11025834
ABSTRACT:
The invention relates to new polypeptide in isolated form belonging to a subfamily of the human Immunoglobulin Superfamily, which polypeptide shows at least 70% sequence homology with the amino acid sequence of the murine Confluency Regulated Adhesion Molecules 1 or 2 (CRAM-1 or CRAM-2) as depicted in FIG.3upper and second row, respectively, and antibodies thereto as well as their use in treatment of inflammation and tumors.
REFERENCES:
patent: 6469155 (2002-10-01), Fiume et al.
patent: 6635468 (2003-10-01), Ashkenazi et al.
patent: 6930172 (2005-08-01), Ferrara et al.
patent: 2005/0136060 (2005-06-01), Imhof et al.
patent: WO 98/24897 (1998-06-01), None
patent: WO 98/42739 (1998-10-01), None
patent: WO 99/06551 (1999-02-01), None
patent: WO 00/36102 (2000-06-01), None
Aurrand-Lions, M. et al. “Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members”Blood, Dec. 15, 2001, pp. 3699-3707, vol. 98, No. 13.
Skolnick, J. et al. “From genes to protein structure and function: novel applications of computational approaches in the genomic era”Trends in Biotech, Jan. 2000, pp. 34-39, vol. 18, No. 1.
Attwood, T. K. “The Babel of Bioinformatics”Science, Oct. 20, 2000, pp. 471-473, vol. 290.
Database EMBL (Online), Accession No. AI154320, Oct. 1, 1998, Marra, M. “EST: Mouse mammary gland cDNA clone Image:1447499”, XP-002144155.
Database EMBL (Online), Accession No. AI1663309, May 11, 1999, Marra, M. “EST:M. musculuscDNA clone Image:1970215 similar to Junctional Adhesion Molecule”, XP-002144156.
Database EMBL (Online), Accession No. AW162934, Nov. 11, 1999, Hillier, L. “EST:H. sapienscDNA clone Image:2783568 similar to Junctional Adhesion Molecule”, XP-002144157.
Martin-Padura, I. et al. “Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration”J. Cell. Biol., Jul. 13, 1998, pp. 117-127, vol. 142, No. 1.
Heath, J.K. et al. “The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily”Proc. Natl. Acad. Sci. USA, Jan. 21, 1997, pp. 469-474, vol. 94, No. 2.
Jermutus, L. et al. “Recent advances in producing and selecting functional proteins by using cell-free translation”Current Opinion in Biotechnology, Oct. 1998, pp. 534-548, vol. 9, No. 5.
Lamagna, C. et al. “Dual Interaction of JAM-C with JAM-B and αMβ2Integrin: Function in Junctional Complexes and Leukocyte Adhesion”Molecular Biology of the Cell, Oct. 2005, pp. 4992-5003, vol. 16, No. 10.
Dufresne, G. et al. “Genetic sequences: how are they patented?”Nature Biotechnology, Feb. 2004, pp. 231-232, vol. 22, No. 2.
Hanes, J. et al. “In vitro selection and evolution of functional proteins by using ribosome display”Proc. Natl. Acad. Sci. USA, May 13, 1997, pp. 4937-4942, vol. 94, No. 10.
Webber, C. et al. “Genes and homology”Current Biology, May 4, 2004, pp. R332-333, vol. 14, No. 9.
Lewin, R. “When Does Homology Mean Something Else?”Science, Sep. 25, 1987, p. 1570, vol. 237, No. 4822.
Sczakiel, G. The design of antisense RNAAntisense Nucleic Acid Drug Dev., Aug. 1997, pp. 439-444, vol. 7, No. 4, abstract only.
Johnstone, C. N. et al. “Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells”Am. J. Physiol Gastrointest Liver Physiol., Sep. 2000, pp. G500-510, vol. 279, No. 3.
Lamagna, C. et al. “Antibody against Junctional Adhesion Molecule-C Inhibits Angiogenesis and Tumor Growth”Cancer Res, Jul. 1, 2005, pp. 5703-5710, vol. 65, No. 13.
Orlova, V. V. et al. “Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts”The Journal of Experimental Medicine, Nov. 27, 2006, pp. 2703-2714, vol. 203, No. 12.
Aurrand-Lions Michel
Imhof Beat Albert
Haddad Maher M
Laboratoires Serono S.A.
Saliwanchik Lloyd & Saliwanchik
LandOfFree
Confluence regulated adhesion molecules useful in modulating... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Confluence regulated adhesion molecules useful in modulating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Confluence regulated adhesion molecules useful in modulating... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3954538