Configuration of glycosaminoglycans

Details Configuration of glycosaminoglycans Configuration of glycosaminoglycans

2005-12-13

2005-12-13

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S055100, C536S053000

Reexamination Certificate

active

06974805

ABSTRACT:
The present invention provides stable glycosaminoglycan (GSG) structures and methods of use of such GAG structures. These structures comprise a core of free GAG, a coating of crosslinked GAG surrounding the core, and a layer of a positively charged moiety surrounding the crosslinked GAG layer. These GAG structures provide improved stability, both in in vivo and external use. Furthermore, resurfacing of the structures provides improved cell adhesion and thus improved delivery of the GAG into living cells and tissues.

REFERENCES:
patent: 5510328 (1996-04-01), Polarek et al.
patent: 5766631 (1998-06-01), Arnold

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