Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1994-06-28
1996-06-11
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
424486, A61K 920
Patent
active
055253520
DESCRIPTION:
BRIEF SUMMARY
The aim of the present invention is to propose a confectionery form of matrix suited to contain microcapsules for controlled release of pharmacologically active substances, of fixed content, which is soluble in the mouth and readily swallowed without chewing, as well as the process for the preparation thereof.
Since the microcapsules for controlled release of pharmacologically active substances are not resistant to the high pressures created in the tabletting machines, tablets containing microcapsules for controlled release of pharmaceutically active substances are rarely manufactured.
Thus, the most widespread form for the oral administration of microcapsules for controlled release of pharmaceutically active substances are the gelatin capsules.
However, many patients and particularly children refuse to swallow a medicine in the form of a usual gelatin capsule available in the market.
In these patients, the feeling that the capsule is a foreign body that may make them choke neutralizes the mechanism of swallowing.
The need consequently exists for the creation of a system of a matrix that would permit the easy oral administration of microcapsules for controlled release of pharmaceutically active substances, which is soluble in the mouth without chewing.
PRIOR STATE-OF-THE-ART
DE-A 336 216 describes a process for coating pharmaceutically active substances for the formation of microcapsules which are resitant to the pressures created during tabletting, nevertheless, it imposes considerable limitations in the selection of materials used for said coating.
FR-A 2011960 renders formulated pieces which include microcapsules containing pharmaceutically active substances administered orally, nevertheless, it presents the disadvantage that the mixture to be formulated is exposed to relatively high temperatures for considerable time, a fact which creates serious risks for alteration or for shortening of the shelf-life of various thermolabile pharmaceutical substances.
Patent Application EP-0 239983 describes a process which avoids the high temperatures employed in FR-A 2011960 but which, despite the fact that it makes use of readily melted mixtures, likewise strains, from the thermal point of view, even though to a smaller extent, the pharmaceutically active substances.
Patent Application EP-0 227603 grants a confectionery system for the administration of medicines by means of chewing but likewise strains, from the thermal point of view, the protected pharmaceutically active substances.
EP-A 0267160 describes a product which is likewise thermically strained in the course of its processing.
DESCRIPTION OF THE INVENTION
In accordance with the present invention, the aforementioned problem is solved by addition of the aforementioned known per se microcapsules for controlled release of pharmaceutically active substances (see for instance U.S.A. 18th Edition Pages 1663-1665 Eds.: Pharmaceutical Dosage Forms--Disperse Systems, Vol. 2 Pharmaceutical Technology, April 1985 Rotary Fluidized-Bed Granulator" Drug Made in Germany, Vol. XXV pp. 61-65 (1982), incorporated to the present description by reference) cream substitute under stirring, at a temperature ranging between -1.degree. C. and 0.degree. C., and its immediate feeding into a device of continuous or non-continuous operation, for production and kneading of ice cream, where it is solidified, under nitrogen bubbling, under pressure, in a matrix for enclosure of microcapsules and it is formulated, preferably, in cup-shaped pieces or in ice cream borne on a small wooden rod, in certain cases of bulky pharmaceuticals, such as for instance in the case of cathartic plant fibers or of nutritive elements, which are administered in large single doses of up to approximately 100 grams, or in the shape of chocolate bars with subdivisions, bonbons, caramels, spheres, sugared pills, cylinders, olives, and in any kind of geometrical or artistic shape, or color, confectionery preparations of this sort, of low weight and of small dimensions, for all medicinal products that are usu
REFERENCES:
patent: 4086370 (1978-04-01), Olds et al.
patent: 4104405 (1978-08-01), Forkner
patent: 4104411 (1978-08-01), Poaler
patent: 4127679 (1978-11-01), Amano et al.
patent: 4725445 (1988-02-01), Ferrero
patent: 4749575 (1988-06-01), Rotman
patent: 4785833 (1988-11-01), Holzner et al.
patent: 4853246 (1989-08-01), Stevens
patent: 4999185 (1991-03-01), Takemori et al.
patent: 5135767 (1992-08-01), Daouse
patent: 5343710 (1994-09-01), Cathenaut et al.
Derwent Publications Ltd., London, GB; AN 90-262116, Database WPI, Week 9035, & DK, A, 8 903 113 (Novo-Nordisk A/S) 13 Jun. 1990.
Derwent Publications Ltd., London, GB; AN 90-035088, Database WPI, Week 9005 & SE, A, 8 800 634 (Semper AB) 25 Aug. 1989.
Derwent Publications Ltd., London, GB; AN 85-185973, Database WPI, Week 8531, & JP, A, 60 112 720 (Kosaka) 19 Jun. 1985.
Derwent Publications Ltd., London, GB; AN 90-120673, Database WPI, Week 9016, & JP, A, 2 072 121 (Yakult Honsha KK et al.) 12 Mar. 1990.
Kontos Angelos
Kontos Georgios C.
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