Confectionery compositions

Drug – bio-affecting and body treating compositions – Dentifrices – Plant extract of undetermined constitution

Reexamination Certificate

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C424S049000, C424S050000, C424S051000, C424S052000, C424S053000, C424S054000, C424S055000, C424S056000, C424S057000, C424S048000, C424S440000, C426S003000, C426S004000, C426S005000, C426S006000, C426S660000

Reexamination Certificate

active

06703000

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates to confectionery compositions that comprise an effective amount of a natural plant extract selected from honeysuckle extract, green tea extract, gold thread extract and magnolia extract and mixtures thereof, an oral care active selected from the group consisting of anti-calculus agents; anti-plaque agents; fluoride ion source desensitising agents; oral malodour control agents; H2 antagonists; and mixtures thereof and wherein the confectionery composition comprises less than 10%, by weight of the composition, water. Preferably this invention relates to non cariogenic or so called “sugar free” confectionery compositions. In particular this invention relates to compositions that have improved ability to combat halitosis of a subject. Compositions of the present invention are suitable for use by humans or animals.
BACKGROUND OF THE INVENTION
Oral malodour or halitosis, which is commonly referred to as bad breath, is the result of volatile sulphur compounds, carboxylic acids and amines building up in the oral cavity. The malodourous compounds are generated primarily through putrefactive action of oral micro organisms on sulphur containing amino acids, peptones or proteins found in the mouth. Such micro-organisms are readily available in saliva and dental plaque and may be derived from proteinaceous food particles trapped between the teeth, in the gingival crevice or adhering to the mucous membranes and the irregular surface of the tongue as well as exfoliated oral epitheleum, food debris and the like. In addition oral malodour may be the result of poor oral hygiene, digestive system problems, disease, diet or a combination of any of these factors. Not only is oral malodour unpleasant but its presence can be indicative of poor oral hygiene and can also be one of the first signs of some more severe underlying problems. This is because the build up of putrid matter which causes malodour can also lead to the formation of plaque, the origin of dental caries, gingivitis and dental calculus. Regular brushing of teeth can help to minimise oral malodour. However, even regular brushing is not sufficient to remove all of the food and oral bacteria deposits that adhere to the oral surfaces and, in severe cases it is unable to eliminate oral malodour.
There is currently a movement in the oral care industry to encourage consumers to use dental hygiene products throughout the day and to brush their teeth more often. However, this is at best inconvenient and is often not possible. As such significant developmental effort has been focused towards developing oral care products in forms which are portable, which can be used several times a day, particularly after eating and which provide anti-plaque and anti-calculus benefits comparable to those obtained by regular brushing with dentifrice. It is hoped that such a product will improve the oral hygiene of consumers. In addition, such a product would make it easier to provide good oral hygiene to children and pets where it is not always easy to regularly brush the teeth.
Confectionery compositions which are popular with both children and adults alike and which are retained in the oral cavity for substantial periods of time during consumption, would seem to make an ideal product form for a portable oral care product. Furthermore chewing gums have many benefits as a portable oral care form since they remain within the oral cavity for significant periods of time, typically 20 minutes or longer. The art of the development and manufacture of a wide range of confectionery compositions is well known. However, the high sugar content of such confectionery compositions has been recognised as a contributory factor in poor dental health. Developments have been made to produce “sugar free”, or non cariogenic, confectionery which retain their organoleptic properties but which do not contribute to the formation of dental plaque. More recently research has turned to developing confectionery compositions, particularly “sugar free” confectionery compositions, particularly chewing gum compositions, which comprise one or more oral care agents. One such example is WO 99/44436 which discloses coated chewing gum compositions which comprise materials with known oral care benefits. There exists a need therefore for a wide range of confectionery compositions which have oral malodour benefits. In addition there is a need for such compositions to be able to deliver a wide range of oral care benefits including more effective oral malodour control benefits thus providing a composition which is able to deliver a wide range of oral care benefits.
To date oral malodour products have been formulated to comprise a wide range of materials that kill the oral bacteria contributing to the oral malodour. Such materials include agents such as triclosan, stannous fluoride, metal cations, chlorhexidine, quaternary ammonium salts and camphorated parachlorophenol. However, these materials can be harsh, and can only be dosed in limited daily amounts and as such are not necessarily suitable for use in a product to be used several times a day. In some cases they may also cause undesirable side effects such as staining, altered taste etc.
More recently trends have been directed towards the use so called natural materials, especially extracts. Herbal curry plant extract has been disclosed in JP 10-182,388 for combating halitosis; cranberry extract has been disclosed in WO 96/28135 for is antimicrobial properties; U.S. Pat. No. 5,741,138 discloses oral compositions comprising gold thread and honeysuckle extracts; and DE 4,221,103 discloses compositions comprising a wide range of herbal extracts for oral hygiene. Polyphenols have been identified as an important active in a wide range of herbal extracts. Examples of polyphenol disclosures include EP 1,046,398 which discloses the use of vegetable polyphenols for treatment of gingivitis; JP 2000-239,136 which discloses the use of
Perilla ocimodes
polyphenol for treatment of caries and periodontal disease; CN 1,141,161 which discloses a health care gargle for oral cleansing comprising polyphenol; JP 9-110,687 which discloses anti-cariogenic and anti-periodontis compositions comprising polyphenols; JP 10-90124 which discloses compositions comprising polyphenols for anti-plaque and anti-periodontis activity; JP 3-284,625 which discloses oral compositions comprising tea leaf extracts; and JP 3-077,817 which discloses mouth wash compositions comprising tea polyphenol for prevention of tooth decay. Furthermore the use of polyphenols has also been disclosed for oral deodorising benefits including WO 01/17494 which discloses dentifrice compositions comprising tea polyphenols; US/PCT/00/11258 which discloses dentifrice compositions comprising polyphenol herbal extracts; and EP 1,013,261 which discloses a spray liquid comprising polyphenol for the masking of halitosis. Whilst the teachings of the prior art are directed towards dentifrice and mouth wash compositions comprising polyphenol materials there remains a need to understand how to stably formulate a wide range of confectionery compositions comprising such materials with improved oral malodour control benefits.
Turning to the confectionery art there are isolated disclosures of compositions comprising polyphenol extracts. These include JP 2000-189,060 which discloses gelatine compositions comprising polyphenol for the removal of teeth staining; JP 10-257856 which discloses a chewing gum composition comprising polyphenol for the prevention of influenza; JP 2000-212,094 which discloses lozenges comprising green tea extract for treating pharyngitis; CN 1,094,895 and CN 1,096,699 which disclose chewing gums comprising magnolia bark extract; CN 1,111,097 which discloses a chewing gum compositions comprising green tea extract; JP 11-302,142 which discloses food stuffs comprising grape, tea or blueberry polyphenol extract; and WO 99/44440 which discloses a food composition comprising tea polyphenol for the prevention of periodontis. However such compositions usua

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