Conditioned media to inhibit growth of tumor cells

Details Conditioned media to inhibit growth of tumor cells Conditioned media to inhibit growth of tumor cells

2007-12-18

2007-12-18

Lankford, Jr., Leon B (Department: 1651)

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

C424S523000, C424S577000, C424S578000

Reexamination Certificate

active

11132797

ABSTRACT:
Conditioned media compositions having valuable biological activity are obtained from cultures of immune cells from elasmobranch fishes. A method is provided for producing the conditioned media compositions. Conditioned media obtained using epigonal cells from bonnethead sharks (Sphyrna tiburo) and lemon sharks (Negaprion brevirostris) demonstrate strong anti-tumor activities. The conditioned media compositions can be used for treating tumor proliferation.

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Walsh CJ, CA Luer, GA Hunter, DR Noyes, CA Smith, M Gasparetto, KN Bhalla, R Nimmanapalli. Bioactive compounds from bonnethead shark Sphyrna tiburo epigonal cells: inhibitory activity against tumor cell lines. American Elasmobranch Society, 18th Annual Meeting, Jul. 3-8, 2002, pp. 300-301, USA.
Walsh CJ, CA Luer, DR Noyes, CA Smith, M Gasparetto, KN Bhalla. Characterization of shark immune cell factor (Sphyrna tiburo epigonal factor, STEF) that inhibits tumor growth by inhibiting S-phase and inducing apoptosis via the TRAIL pathway. FASEB J, vol. 18, No. 4, Mar. 23, 2004, pp. A60-A61, Washington DC ,USA.
Walsh CJ, CA Luer, DR Noyes, CA Smith, M Gasparetto, KN Bhalla. Characterization of shark immune cell factor (Sphyrna tiburo epigonal factor, STEF) that inhibits tumor growth by inhibiting S-phase and inducing apoptosis via the TRAIL pathway. Experimental Biology 2004, Apr. 17-21, 2004, Washington DC, USA.

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