Condensed thiophene compound and pharmaceutical use thereof

Details Condensed thiophene compound and pharmaceutical use thereof Condensed thiophene compound and pharmaceutical use thereof

1994-07-08

1996-07-02

Datlow, Philip I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514301, 540461, 540521, 540593, 544362, 546114, A61K 31435, C07D49504

Patent

active

055322409

ABSTRACT:
A condensed thiophene compound represented by general formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein ring S represents a thiophene ring; R.sup.1 represents hydrogen, halogen, alkyl, etc.; R.sup.2 represents hydrogen, alkyl, acyl, etc.; G represents --CH.sub.2 --, --CH(OH)--, --CO--, etc.; Q represents alkylene; T represents --N(Rb)(Rc) (wherein Rb, Rc represents each alkyl etc.; or alternatively Rb and Rc are combined together to form cyclic amino); D represents --CH.sub.2 -- or --S--; A and B represent each carbonyl or thiocarbonyl, or are null; and m and n represent each 0, 1 to 4, provided that m+n represents an integer of 4 or less.
This compound is useful as an antipsychotic drug having a reduced extrapyramidal side effect.

REFERENCES:
patent: 4352811 (1982-10-01), Strupczewski et al.
patent: 4414225 (1983-11-01), Sauter et al.
patent: 4458076 (1984-07-01), Strupczewski
patent: 4482559 (1984-11-01), Schneider et al.
patent: 4524206 (1985-06-01), New et al.
patent: 4735940 (1988-04-01), Fischer et al.
patent: 4812461 (1989-03-01), Antoku et al.
patent: 4937249 (1990-06-01), Antoku et al.
patent: 4948799 (1990-08-01), Antoku et al.
patent: 5173490 (1992-12-01), Peglion et al.
Chemical Abstracts, vol. 55, Column 23488b (1961), Fabrichnyi et al.
Chemical Abstracts, vol. 59, Column 3862a (1963), Nishimura et al.
Chemical Abstracts, vol. 64, Column 586c (1966) Fabrichnyi et al.
Chemical Abstracts, vol. 69, 18565x (1968), Fabrichnyi et al.
J. Heterocyclic Chem., vol. 13, pp. 1347-1349 (1976) (with English Summary), Maffrand et al.

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