Condensed thiazole compounds and use as pharmaceuticals

Details Condensed thiazole compounds and use as pharmaceuticals Condensed thiazole compounds and use as pharmaceuticals

1991-02-22

1992-10-06

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142342, 514253, 514254, 514367, 544127, 544405, 546114, 548153, A61K 31435, C07D51304

Patent

active

051532018

ABSTRACT:
A novel condensed thiazole derivative of the formula [I]: ##STR1## wherein A is a single bond or CH.sub.2 ; R.sup.1 is hydrogen atom, or an optionally substituted aliphatic, carboxylic acyl or sulfonic acyl group; and R.sup.2 is hydrogen atom, or an optionally substituted aromatic cyclic or aliphatic group, or a salt thereof. The compound [I] is useful for medicines for preventing and treating various diseases such as cancer, arterial sclerosis, hepatopathy, cerebrovascular diseases, inflammatory and the like. A process of the compound of the formula [I] or a salt thereof and a pharmaceutical composition comprising the compound of the formula [I] or a pharmaceutically acceptable salt thereof as an active component are also disclosed.

REFERENCES:
Ivan A. Natchev, "Phosphono and Phosphino Analogues and Derivatives of the Natural Aminocarboxylic Acids and Peptides 1. Synthesis and Enzyme-Substrate Interactions of N-Phosphono-, and N-Phosphinomethylated Cyclic Amides", Synthesis, No. 12, Dec. 1987, pp. 1079-1084.
Chemical Abstracts, vol. 50, 14753a (1956); Fridman, Zhur. Obshchei, vol. 26, pp. 864-867 (1956).

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