Condensed thiadiazole derivative, method of its production, and

Details Condensed thiadiazole derivative, method of its production, and Condensed thiadiazole derivative, method of its production, and

1993-03-23

1996-08-27

Gibson, Sharon

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548130, C07D51304, A61K 31435

Patent

active

055501389

ABSTRACT:
(1) a compound represented by the following formula (I): ##STR1## wherein R represents a hydrocarbon group or heterocyclic group which may be substituted; the ring A represents a pyridine ring having a substituent or a thiazole ring which may be substituted; or a pharmaceutically acceptable salt thereof, and a method of its production, and
(2) an endothelin receptor antagonist, an cathepsin B inhibitor or a bone resorption suppressor having as an active ingredient a compound represented by the following formula (I'): ##STR2## wherein R has the same definition as in term (1); the ring A' represents a pyridine ring or thiazole ring which may be substituted; or a pharmaceutically acceptable salt thereof.

REFERENCES:
Biochemical Pharmacology, vol. 44, No. 6, Sep. 25, 1992, pp. 1201-1207.
Chemical Abstracts, vol. 114, No. 3, Jan. 21, 1991, p. 696, Abstract No. 23848u.

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