Condensed-ring thiophene derivatives and thienopyrimidine deriva

Details Condensed-ring thiophene derivatives and thienopyrimidine deriva Condensed-ring thiophene derivatives and thienopyrimidine deriva

1996-07-17

2000-04-11

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544127, 544278, 544238, 546114, 5142342, 514253, 514254, 514301, A61K 31505, C07D49504

Patent

active

060488638

ABSTRACT:
Thienopyrimidine derivatives of formula: ##STR1## The present thienopyrimidine derivatives are useful for treating mammals suffering from disorders related to gonadotropin realeasing hormone (GnRH).

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Schally et al., "Isolation of the Luteinizing Hormone and Follicle-Stimulating Hormone-Releasing Hormone from Porcine Hypothalami", The Journal of Biological Chemistry, vol. 246, No. 23, (1971), pp. 7230-7236.
Burgus et al., "Primary Structure of the Ovine Hypothalamic Luteinizing Hormone-Releasing Factor (LRF)", Proceedings of the National Academy of Sciences, vol. 69, No. 1 (1972) pp. 278-282.
Bienstock et al., "Conformational Analysis of a Highly Potent Dicyclic Gonadotropin-Releasing Hormone Antagonist by Nuclear Magnetic Resonance and Molecular Dynamics", Journal of Medicinal Chemistry, vol. 36, (1993), pp. 3265-3273.
Reissmann et al., Human Reproduction, vol. 10, pp. 1974-1981, 1995.

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