Condensed pyrrolinone derivatives, their production and use

Details Condensed pyrrolinone derivatives, their production and use Condensed pyrrolinone derivatives, their production and use

1983-03-24

1986-05-20

Lesmes, George F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544373, 546113, 544120, 546159, 546160, 544122, 546163, 546201, 544124, 548159, 548181, 544128, 548468, 544133, 260239B, 514311, 544135, 514339, 514323, 544144, 514365, 514416, 544295, 514227, 544311, 514253, 514254, 544312, 514256, 544313, 544314, 544315, 544316, 544317, 544318, 544319, 544320, 544323, 544325, 544329, 544330, 544332, 544334, 544335, 544357, 544359, 544360, 544362, 544363, 544368, 544369, C07D41302, C07D40304, C07D40102, C07D47104, C07D20902, A61K 31535, A61K 31505, A61K 31495, A61K 3147, A

Patent

active

045901899

ABSTRACT:
The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is --CH.dbd.CH--CH.dbd.CH--, --S--(CH.sub.2).sub.l --S--(l is an integer of 1 to 3), --N.dbd.CH--CH.dbd.N-- or --(CH.sub.2).sub.m --(m is an integer of 3 to 5); ring A may optionally be substituted with halogen, nitro, amino, alkanoylamino, alkoxycarbonyl, carboxyl or carbamoyl; and n is an integer of 1 to 3, and salts thereof. The compounds display a strong antianxiety effect to mammalian animals and are useful for the prevention or treatment of a disease such as psychosomatic disease and anxiety neurosis.

REFERENCES:
patent: 2957872 (1960-10-01), Huebner
patent: 3579524 (1971-05-01), VanDyke, Jr.
patent: 3818011 (1974-06-01), Challier et al.
patent: 3853880 (1974-12-01), Challier et al.
patent: 3898232 (1975-08-01), Cotrel et al.
patent: 4016274 (1977-04-01), Cotrel et al.
patent: 4038391 (1977-07-01), Cotrel et al.
patent: 4355031 (1982-10-01), Demerson et al.

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