Condensed pyridines and pyrimidines with tie2 (TEK) activity

Details Condensed pyridines and pyrimidines with tie2 (TEK) activity Condensed pyridines and pyrimidines with tie2 (TEK) activity

2003-08-01

2008-09-23

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S233800, C514S234200, C514S234800, C514S257000, C514S260100, C514S263200, C514S265100, C544S105000, C544S116000, C544S117000, C544S255000, C544S264000, C544S266000, C544S280000

Reexamination Certificate

active

07427616

ABSTRACT:
A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I): G is selected from O, S and NR5; Z is selected from N and CR6; Q1is selected from optionally substituted aryl and heteroaryl, and the substituents R1to R6are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.

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