Condensed purine derivatives

Details Condensed purine derivatives Condensed purine derivatives

1990-10-19

1993-12-14

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544251, 544265, 544273, 544276, A61K 3152, C07D48714

Patent

active

052703169

ABSTRACT:
There are disclosed condensed purine derivatives represented by formula; ##STR1## in which R.sup.3 represents hydrogen, lower alkyl or benzyl; each of X.sup.1 and X.sup.2 independently represents hydrogen, lower alkyl, aralkyl or phenyl; and n is an integer of 0 or 1; R.sup.1 represents hydrogen, lower alkyl, alicyclic alkyl, noradamantan-3-yl, dicyclopropylmethyl or styryl; and R.sup.2 represents hydrogen, lower alkyl or alicyclic alkyl; or a pharmaceutically acceptable salt thereof. The derivatives and pharmaceutically acceptable salts are useful as diuretics, renal protecting agents, antiallergic agents and hypotensives.

REFERENCES:
patent: 4298734 (1981-11-01), Temple, Jr.
patent: 5064947 (1991-11-01), Peet et al.
patent: 5086176 (1992-04-01), Peet et al.
Sepiol et al., Chemical Abstracts, vol. 86: 29222k (1987).
Ohsaki et al., Chemical Abstracts, vol. 106: 84536x (1987).
Habraken et al., Chemical Abstracts, vol. 112: 191473v May 21, 1990.
Temple et al. J. Med. Chem., vol. 23, No. 11, pp. 1188-1198 (1980).
Ienaga et al. Liebigs Ann. Chem., vol. 11, pp. 1972-1880 (1979).

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